Effective delivery of chemotherapeutic nanoparticles by depleting host Kupffer cells

International Journal of Cancer. Journal International Du Cancer
Yusuke OharaNobuhiro Ohkohchi

Abstract

Although chemotherapeutic nanoparticles would confer various advantages, the majority of administrated nanoparticles are known to be spoiled by the reticuloendothelial system (RES). Intending to more effectively deliver therapeutic nanoparticles to target regions in vivo, host RES, especially Kupffer cells in the liver, have been depleted ahead of drug administration. To demonstrate this hypothesis, clodronate liposomes were preinjected into BALB/c nude mice for depletion of Kupffer cells 2 days before, and pegylated liposomal doxorubicin (Doxil) at the doses of 1.25, 2.5 and 5.0 mg/kg was administered. As a result, doxorubicin accumulation in the liver was decreased from 36 to 26% injected dose/organ by the Kupffer cells depletion, and consequently, the plasma concentration of doxorubicin was significantly enhanced threefold (from 11 to 33 μg/mL) on day 1 at 1.25 mg/kg-dose group. Doxorubicin accumulation in the tumor was increased from 0.78 to 3.0 μg/g-tissue on day 3, and tumor growth inhibition by Doxil was significantly boosted (tumor volumes from 751 to 482 mm(3) on day 24) by the Kupffer cells depletion. In conclusion, Kupffer cells depletion by clodronate liposomes enhanced the plasma concentration and antitumor effects...Continue Reading

References

Aug 14, 1992·Biochimica Et Biophysica Acta·M C Woodle, D D Lasic
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Oct 4, 1989·Journal of the National Cancer Institute·A GabizonD Papahadjopoulos
May 29, 1995·International Journal of Cancer. Journal International Du Cancer·T DaemenG L Scherphof
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Mar 18, 1994·Science·R GrefR Langer
Apr 11, 1996·Nature·D D Lasic
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N Van Rooijen, A Sanders
Jun 9, 2001·International Journal of Pharmaceutics·Z PanagiK Avgoustakis
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A N GordonA J Lacave
Jan 16, 2002·Critical Reviews in Therapeutic Drug Carrier Systems·P LavermanG Storm
Feb 27, 2003·Journal of Liposome Research·Nico van Rooijen, Esther van Kesteren-Hendrikx
Jul 17, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M G A van IJkenA M M Eggermont
Sep 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William J GradisharJoyce O'Shaughnessy
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert D ArnoldRobert M Straubinger
Aug 29, 2006·Drug Discovery Today·Arun K IyerHiroshi Maeda
Nov 11, 2006·Japanese Journal of Clinical Oncology·Yasuhito FujisakaTomohide Tamura
Jan 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dmitri SimbergErkki Ruoslahti
Aug 10, 2007·Biomaterials·Timothy JamiesonAlexander M Seifalian
Aug 25, 2007·Nanomedicine·Ken Donaldson
Jan 15, 2008·Urologic Oncology·Frank AlexisOmid C Farokhzad
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kwangjae ChoDong M Shin
Oct 20, 2009·Trends in Pharmacological Sciences·Yogeshkumar MalamAlexander M Seifalian
Mar 17, 2010·The Journal of Cell Biology·Erkki RuoslahtiMichael J Sailor
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos

❮ Previous
Next ❯

Citations

May 30, 2013·International Journal of Nanomedicine·Antonina OrlandoEmanuela Cazzaniga
Jul 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jantana YahuafaiNaoto Oku
May 9, 2015·International Journal of Oncology·Yoshiyuki HattoriEtsuo Yonemochi
Feb 3, 2016·Biological & Pharmaceutical Bulletin·Masami UkawaTatsuhiro Ishida
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Nan ZhangWarren C W Chan
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Wanisa PunfaPornngarm Limtrakul
Apr 4, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Max KullbergThomas J Anchordoquy
Oct 1, 2016·Expert Opinion on Drug Delivery·Ayesha KhalidJoy Wolfram
Dec 7, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anthony J TavaresWarren C W Chan
Sep 11, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicholas B SobolJason S Lewis
Oct 22, 2017·The FEBS Journal·Massimiliano MazzoneAlessandra Castegna
Sep 19, 2020·Journal of Extracellular Vesicles·Zakia BelhadjQiang Zhang
Apr 3, 2020·Biological & Pharmaceutical Bulletin·Ikramy A KhalilHideyoshi Harashima
Aug 12, 2020·Nature Materials·Ben OuyangWarren C W Chan
Aug 22, 2020·International Journal of Nanomedicine·Mee-Sup Yoon
Mar 23, 2021·Acta Pharmaceutica Sinica. B·Iara Maíra de Oliveira VianaNicolas Bertrand
Jul 29, 2021·Journal of Biomedical Materials Research. Part a·Marian A Ackun-FarmmerDanielle S W Benoit
May 2, 2020·Nano Letters·Nell R M SaundersRobert Langer
Dec 5, 2019·ACS Nano·Keegan Guidolin, Gang Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.