Effective hard particle model for the osmotic pressure of highly concentrated binary protein solutions.

Biophysical Journal
Allen P Minton

Abstract

The experimentally measured concentration dependence of the osmotic pressure of an equimolar mixture of hen egg ovalbumin and bovine serum albumin at pH 7.0 and 25 degrees C in the presence of 0.15 M NaCl is shown to be quantitatively accounted for by a model in which each protein species is represented by an effective hard sphere. The size of this sphere is determined by analysis of the concentration dependence of the osmotic pressure of the isolated protein.

References

Jun 1, 1978·Analytical Biochemistry·D Malamud, J W Drysdale
Jul 25, 2003·Biochimica Et Biophysica Acta·Damien Hall, Allen P Minton

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Citations

Dec 24, 2010·The Journal of Physical Chemistry. B·Cristina Fernández, Allen P Minton
Oct 1, 2008·Journal of Pharmaceutical Sciences·Hanns-Christian MahlerSylvia Kiese
Feb 5, 2015·Biophysical Journal·Prasad S SarangapaniJai A Pathak
Feb 5, 2015·Biophysical Journal·John Prausnitz
Apr 19, 2011·International Journal of Pharmaceutics·Christopher J RobertsErinc Sahin
Mar 10, 2016·Scientific Reports·Takamitsu J MorikawaTomonobu M Watanabe
Feb 25, 2014·Biophysical Journal·David P Goldenberg, Brian Argyle
Oct 30, 2016·Trends in Biochemical Sciences·Germán Rivas, Allen P Minton
Dec 14, 2017·Biophysics Reviews·Germán Rivas, Allen P Minton
Jan 1, 2018·Nature Physics·Joe Chin-Hun KuoMatthew J Paszek
Jun 25, 2008·Annual Review of Biophysics·Huan-Xiang ZhouAllen P Minton

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