Effective infrared absorption coefficient for photothermal radiometric measurements in biological tissues

Physics in Medicine and Biology
B Majaron, Matija Milanic

Abstract

Although photothermal radiometric (PTR) measurements commonly employ broad-band signal acquisition to increase the signal-to-noise ratio, all reported studies apply a fixed infrared (IR) absorption coefficient to simplify the involved signal analysis. In samples with large spectral variation of micro(lambda) in mid-IR, which includes most biological tissues, the selection of the effective IR absorption coefficient value (micro(eff)) can strongly affect the accuracy of the result. We present a novel analytical approach for the determination of optimal micro(eff) from spectral properties of the sample and radiation detector. In extensive numerical simulations of pulsed PTR temperature profiling in human skin using three common IR radiation detectors and several acquisition spectral bands, we demonstrate that our approach produces viable values micro(eff). Two previously used analytical estimations perform much worse in the same comparison.

References

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Aug 29, 2000·Lasers in Surgery and Medicine·W VerkruysseJ S Nelson
Jul 11, 2002·Physics in Medicine and Biology·Boris MajaronJ Stuart Nelson
Apr 7, 2004·Journal of Biomedical Optics·Bernard ChoiJ Stuart Nelson
May 25, 2007·Lasers in Medical Science·Matija MilanicJ Stuart Nelson
May 1, 1993·Applied Optics·S L JacquesT E Milner
Jul 1, 1997·Journal of Biomedical Optics·U S Sathyam, S A Prahl

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Citations

Jan 7, 2009·Journal of Biomedical Optics·Matija MilanicJ Stuart Nelson
Jan 12, 2010·Journal of Biomedical Optics·Matija Milanic, Boris Majaron
Jun 23, 2019·Lasers in Surgery and Medicine·Matija MilanicMatjaz Lukac
Nov 9, 2020·Lasers in Surgery and Medicine·Lewis McMillanKenneth Wood

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