PMID: 11926384Apr 3, 2002Paper

Effective local control of malignant melanoma by intratumoural injection of a beta-emitting radionuclide

European Journal of Nuclear Medicine and Molecular Imaging
Jong Doo LeeKyung Bae Park

Abstract

Intratumoural injection of an unsealed beta-emitting radionuclide is a new technique for the local control of tumours that has the advantage of delivering a higher radiation dose to tumour while minimising radiation hazard to the surrounding normal tissues. In this study, therapeutic effect, morphological alterations and biological responses to the high-dose continuous irradiation delivered using this new technique were evaluated in an animal model with B16 melanoma. For evaluation of the therapeutic effect, 92 C57BL/6 mice with B16 melanoma were divided into four groups. In each group, intratumoural injections were performed when the tumour measured approximately 1 cm along its long axis. Group 1 (n=25) received 0.3 ml of normal saline, group 2 (n=15) 37 MBq of carrier-free holmium-166 in 0.3 ml saline, group 3 (n=27) 185 MBq of 166Ho in 0.3 ml saline and group 4 (n=25) 185 MBq of 166Ho in 0.5 ml saline. In addition, another 30 mice were used for morphological and biological analysis of the radiation effect. These 30 mice were injected with 185 MBq of 166Ho in 0.3 ml saline, and five were sacrificed at each of the following six time points: before injection and 1, 2, 3, 6 and 14 days post injection. Haematoxylin-eosin (H&E) st...Continue Reading

Citations

May 2, 2003·European Journal of Nuclear Medicine and Molecular Imaging·David ErikssonTorgny Stigbrand
May 9, 2003·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jae Min JeongMyung Chul Lee
Dec 8, 2017·Journal of Radiation Oncology·Robbert C BakkerJ Frank W Nijsen
Mar 4, 2005·Yonsei Medical Journal·Ryoong HuhJin Woo Chang
Jul 6, 2004·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Joo Hee KimSung Joon Hong
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Nienke J M KlaassenJ Frank W Nijsen
Jan 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ja Kyung KimYoung Myoung Moon
Dec 6, 2003·Reproductive Biomedicine Online·Sergio OehningerStephen Beebe

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