Effective polymeric dispersants for vacuum, convection and freeze drying of drug nanosuspensions

International Journal of Pharmaceutics
Sujung Kim, Jonghwi Lee

Abstract

Drying nanosuspensions into redispersable powders is a critical issue in developing solid dosage forms of drug nanoparticles. The particle fusion and chain entanglement of polymeric steric stabilizers adsorbed onto the nanoparticle surface should be prevented to retain redispersibility after drying. Herein, we report that only a small amount of polymeric dispersants such as carrageenan, gelatin, and alginic acid between 0.5 and 3 wt.% in various drug nanosuspensions can provide sufficient redispersibility in vacuum, convection, and freeze drying. In vacuum and freeze drying of naproxen nanosuspensions, the addition of only 0.5 wt.% carrageenan resulted in the formation of redispersable nanoparticulate powders. The amounts of polymeric dispersants required for redispersibility was lowest for carrageenan and highest for gelatin. The specific interactions between the dispersants and steric stabilizers (or drugs), in addition to viscosity increase during drying, appeared to effectively prevent irreversible particle aggregation.

References

Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·C Schmidt, R Bodmeier
Oct 9, 1999·Journal of Pharmaceutical Sciences·T KristmundsdóttirH Thormar
Mar 4, 2000·International Journal of Pharmaceutics·M J GrauR H Müller
Nov 10, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A SaezM R Aberturas
Mar 19, 2002·International Journal of Pharmaceutics·Yvette N KonanEric Allémann
Sep 23, 2003·Journal of Pharmaceutical Sciences·Jonghwi Lee
Oct 23, 2004·Pharmaceutical Research·Elaine Merisko-LiversidgeGary G Liversidge
Jan 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jonghwi Lee, Yu Cheng
Apr 20, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wassim AbdelwahedHatem Fessi
Aug 16, 2006·Drug Development and Industrial Pharmacy·A-M LayreR Gref
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·Samuli HirsjärviJouni Hirvonen
Nov 23, 2006·Advanced Drug Delivery Reviews·Wassim AbdelwahedHatem Fessi
Jul 3, 2007·Advanced Drug Delivery Reviews·Filippos KesisoglouYunhui Wu
Feb 12, 2008·International Journal of Pharmaceutics·J LeeC H Park
May 30, 2008·Pharmaceutical Research·Mahesh V Chaubal, Carmen Popescu
Jul 23, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bernard Van EerdenbrughGuy Van den Mooter

❮ Previous
Next ❯

Citations

Jan 25, 2013·Therapeutic Delivery·Carlos E FigueroaRobert K Prud'homme
Dec 18, 2013·International Journal of Pharmaceutics·Anagha BhakayRajesh Dave
Sep 18, 2014·Expert Opinion on Drug Delivery·Susana Mn SimõesCarmen Alvarez-Lorenzo
Oct 21, 2011·Drug Development and Industrial Pharmacy·Hwanki Ho, Jonghwi Lee
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
Nov 28, 2014·Pharmaceutical Development and Technology·Yue-Qin MaXian-Fei Li
Jan 8, 2013·International Journal of Pharmaceutics·Ana M CerdeiraBruno Gander
Jan 23, 2016·Advances in Colloid and Interface Science·Waseem Kaialy, Maen Al Shafiee
Aug 11, 2012·International Journal of Pharmaceutics·Nae-Oh ChungJonghwi Lee
Jan 27, 2015·International Journal of Pharmaceutics·Pengfei YueMing Yang
Oct 10, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Bao-de ShenHai-long Yuan
May 24, 2016·Pharmaceutics·Annika TuomelaLeena Peltonen
Sep 3, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanbiao XieMing Yang
Aug 24, 2018·Pharmaceutics·Maria Rosa GigliobiancoPiera Di Martino
Dec 28, 2019·AAPS PharmSciTech·Mohamed S MohamedAhmed M Samy
Nov 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Roya KoshaniTheo G M van de Ven
Jun 7, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Meng LiEcevit Bilgili
May 31, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eduard Trenkenschuh, Wolfgang Friess

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
B Van EerdenbrughG Van den Mooter
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jonghwi Lee, Yu Cheng
© 2021 Meta ULC. All rights reserved