Effective prophylaxis of influenza A virus pneumonia in mice by topical passive immunotherapy with polyvalent human immunoglobulins or F(ab')2 fragments

Clinical and Experimental Immunology
F RamisseJ M Alonso

Abstract

The effectiveness of polyvalent plasma-derived human immunoglobulins (IVIG) in passive immunotherapy of influenza virus pneumonia was assessed, using the Strain Scotland (A/Scotland/74 (H3N2)) adapted to BALB/c mice by repeated lung passages. Haemagglutinin antibodies in two batches of IVIG at 10 mg/ml had a titre of 1/16. Intravenous injection of 1000-5000 microg of IVIG, 3 h after infection, gave 60-70% protection, whereas intranasal injection of 25-50 microg protected 90% of mice infected with a lethal dose of influenza virus. F(ab')2 fragments were at least as protective as intact IVIG, suggesting that complement or Fcgamma receptor-bearing cells were not required. Topical passive immunotherapy with IVIG or F(ab')2 gave protection up to 8 h after infection, but not at 24 h, suggesting that anti-influenza A antibodies in IVIG, delivered locally, are only effective at early stages of the infectious process. The potential value of topical administration of IVIG or F(ab')2 fragments for influenza A pneumonia prophylaxis was further demonstrated by the protective effects of their intranasal administration 24 h before challenge.

References

Jan 1, 1979·British Medical Bulletin·J L VirelizierG C Schild
Jan 1, 1992·Annual Review of Immunology·P C DohertyS R Carding
Jul 11, 1991·The New England Journal of Medicine·E R Stiehm
Jul 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Casadevall, M D Scharff
Jul 1, 1995·The Journal of Infectious Diseases·M G OttoliniG A Prince

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Citations

Oct 21, 2014·Influenza Research and Treatment·Cassandra M BerryMark Y Sangster
Nov 5, 2004·Médecine sciences : M/S·Christelle DreffierJean-Michel Alonso
Jul 23, 2004·Expert Opinion on Biological Therapy·David W Grainger
Mar 11, 2008·Antiviral Research·John Beigel, Mike Bray
Mar 29, 2011·Expert Opinion on Pharmacotherapy·Paolo Preziosi
Oct 23, 2015·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Zhuo ZhangShimin Zheng
May 22, 2003·FEMS Microbiology Letters·Jean-Michel AlonsoMuhamed-Kheir Taha
Jul 13, 2002·Journal of Medical Virology·Masayoshi ShinjohKuniaki Nerome
Jul 10, 1999·Clinical Microbiology Reviews·R Weltzin, T P Monath

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