PMID: 8615453Apr 1, 1996Paper

Effective, single-dose treatment or porcine cysticercosis with oxfendazole

The American Journal of Tropical Medicine and Hygiene
Armando GonzalesM T Lopez-Urbina

Abstract

The pig is a vital link in the transmission cycle of Taenia solium, the cestode responsible for human-porcine cysticercosis. Infected pigs also represent an important source of economic loss to farmers in developing countries. Past efforts to find an adequate therapeutic regimen to treat this parasite disease in swine have failed because of low efficacy, high cost, side effects, or the need for multiple doses. In this randomized, no treatment-controlled study, the efficacy and safety of oxfendazole and praziquantel for the treatment of porcine cysticercosis were evaluated in 16 naturally infected pigs. Four groups of four pigs were treated with oxfendazole, praziquantel, oxfendazole plus praziquantel, or untreated. The pigs were humanely killed 12 weeks post-treatment, the number of cyst was counted, and parasite viability was assessed by cyst evagination. No detectable side effects were seen in any of the pigs. Praziquantel treatment alone appeared to reduce the number of cysts, but did not decrease the viability of the remaining parasites. Treatment with oxfendazole alone or oxfendazole plus praziquantel killed all of the parasites, and left only microcalcifications in the meat. Oxfendazole provides, for the first time, a pra...Continue Reading

Associated Clinical Trials

Citations

Mar 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·H H GarcíaA E Gonzalez
Jul 27, 2011·Current Opinion in Infectious Diseases·Hector H GarciaRobert H Gilman
Aug 3, 2012·The American Journal of Tropical Medicine and Hygiene·Armando E GonzalezUNKNOWN Cysticercosis Working Group in Peru
Oct 21, 2014·PLoS Neglected Tropical Diseases·Carmen S ArriolaRobert H Gilman
Jun 16, 2016·The New England Journal of Medicine·Hector H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jan 16, 2004·The New England Journal of Medicine·Héctor H GarciaUNKNOWN Cysticercosis Working Group in Peru
Jul 2, 2004·Vector Borne and Zoonotic Diseases·Akira ItoMarshall W Lightowlers
Aug 13, 2013·PLoS Neglected Tropical Diseases·Ernatus Martin MkupasiMaria Vang Johansen
Jun 6, 2012·PLoS Neglected Tropical Diseases·Alberto PondjaMaria Vang Johansen
Dec 26, 2012·Pathogens and Global Health·Robert H GilmanUNKNOWN Cysticercosis Working Group in Peru
Feb 24, 2015·International Journal of Toxicology·Ellen E CoddUNKNOWN Cysticercosis Working Group in Peru
Nov 20, 2018·Theoretical Biology & Medical Modelling·Marco V JoséJuan Pedro Laclette
May 29, 2020·Clinical Microbiology Reviews·Hector H GarciaRobert H Gilman
Apr 16, 2004·The New England Journal of Medicine·Ignacio Rojas-Flores
Mar 15, 2012·Journal of Travel Medicine·Hector H Garcia, UNKNOWN Cysticercosis Working Group in Peru
Sep 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jasim UddinJon S Friedland
Dec 29, 2009·Wiener klinische Wochenschrift·Andrea Sylvia WinklerErich Schmutzhard
Nov 6, 2015·Parasite Immunology·M W LightowlersB Abela-Ridder
Sep 12, 2017·PLoS Neglected Tropical Diseases·Meritxell DonadeuBernadette Abela-Ridder
Dec 7, 2018·Expert Review of Anti-infective Therapy·Armando E GonzalezRobert H Gilman
Jun 17, 2011·Animal Health Research Reviews·S M S AfonsoE V Noormahomed
Feb 7, 2016·Asian Pacific Journal of Tropical Medicine·Ana Vargas-CallaArmando E Gonzalez
Mar 28, 1998·Antimicrobial Agents and Chemotherapy·R E BlantonP M Schantz
Nov 19, 1997·The Veterinary Record·A E GonzalezR H Gilman
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·E L DuegerR H Gilman
Mar 5, 2019·Experimental Parasitology·Laura CeballosLuis Alvarez
Aug 23, 2003·Lancet·Héctor H GarcíaUNKNOWN Cysticercosis Working Group in Peru
Jun 21, 2021·Drug Delivery and Translational Research·Yuzhu SunShuyu Xie
Aug 24, 2021·Emerging Infectious Diseases·Seth E O'NealUNKNOWN Cysticercosis Working Group in Peru
Jun 30, 2009·Veterinary Parasitology·P DornyS Gabriel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.