Effective suppression of parathyroid hormone by 1 alpha-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism

Kidney International
A U TanJ W Coburn

Abstract

Calcitriol, as used for treating secondary hyperparathyroidism, has a low therapeutic index. The safety and efficacy of the vitamin D analog, 1 alpha (OH)-vitamin D2, (1 alpha D2), which has less toxicity in animals than 1 alpha (OH)-vitamin D3, was tested in a multicenter study of 24 hemodialysis patients with secondary hyperparathyroidism [serum intact (i) PTH > 400 pg/ml]. Calcium-based phosphate binders alone were used to maintain serum phosphorus < or = 6.9 mg/dl. After eight weeks without calcitriol (washout), oral 1 alpha D2, 4 micrograms/day or 4 micrograms thrice weekly, was started, with the dose adjusted over 12 weeks to maintain serum iPTH between 130 and 250 pg/ml. Pre-treatment serum iPTH fell from 672 +/- 70 pg/ml (SEM) to 289 +/- 36 after treatment (P < 0.05). The maximal decrease in serum iPTH was 48 to 96%, with 87.5% of patients reaching target iPTH levels. The final dose of 1 alpha D2 average 14.2 micrograms/week. Pre-treatment serum calcium rose modestly from 8.8 +/- 0.2 mg/dl to 9.5 +/0 0.2 after treatment (P < 0.001). Only once did modest hypercalcemia (serum Ca > 11.2 mg/dl) necessitate stopping treatment. Neither the average serum P level, the incidence of hyperphosphatemia, nor the dose of phosphate bi...Continue Reading

References

Jun 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M Sprague, S M Moe
Jul 1, 1992·The Journal of Clinical Endocrinology and Metabolism·L D QuarlesG Murphy
Nov 1, 1991·Journal of the American Society of Nephrology : JASN·M RodriguezF Llach
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F SatoH Orimo
Aug 3, 1989·The New England Journal of Medicine·D L AndressD J Sherrard
Sep 1, 1989·The Journal of Clinical Investigation·A J BrownE Slatopolsky
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J SilverL M Sherwood
Mar 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·G SjödenH F DeLuca
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F LlachS Cerezo
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E SlatopolskyH DeLuca
May 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C GallagherH F DeLuca
Feb 1, 1993·Kidney International·D J SherrardG V Segre
Mar 1, 1996·Journal of the American Society of Nephrology : JASN·B S Levine, M Song

❮ Previous
Next ❯

Citations

Feb 4, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isidro B Salusky
Apr 15, 2003·Chemistry and Physics of Lipids·Neslihan Toyran, Feride Severcan
Aug 21, 2002·Trends in Endocrinology and Metabolism : TEM·Theodore C Friedman, Keith C Norris
Jan 24, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Alex J Brown, Eduardo Slatopolsky
Jan 14, 2000·Kidney International. Supplement·E SlatopolskyA Brown
Jan 14, 2000·Kidney International. Supplement·J Cunningham
Jul 12, 2002·Kidney International·Hartmut H MallucheNicholas J Koszewski
Jun 26, 2001·Seminars in Dialysis·J S Lindberg
Mar 5, 2002·Seminars in Dialysis·Dennis L Andress
Mar 23, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N J Schroeder, J Cunningham
Mar 4, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Geoffrey A BlockUNKNOWN TARGET Investigators
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·K UhligA K Singh
Feb 5, 2002·Annual Review of Physiology·Joost G J HoenderopRene J M Bindels
Apr 19, 2005·Treatments in Endocrinology·Alex J Brown, Daniel W Coyne
Jun 4, 2008·Internal Medicine·Hirotaka KomabaMasafumi Fukagawa
Aug 2, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly KramerMichael V Rocco
Mar 21, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Alex J Brown
Oct 25, 2011·Expert Opinion on Pharmacotherapy·Fellype Carvalho BarretoVanda Jorgetti
May 2, 2003·Expert Opinion on Investigational Drugs·Mark S Stein, John D Wark
Nov 10, 2010·Expert Opinion on Biological Therapy·Hirotaka KomabaMasafumi Fukagawa
Mar 30, 2005·Expert Opinion on Pharmacotherapy·Angel L M de Francisco
May 20, 2003·Kidney International. Supplement·Eduardo SlatopolskyAlex Brown
Feb 22, 2008·Kidney International·C P Kovesdy, K Kalantar-Zadeh
Nov 27, 2008·Kidney International. Supplement·Mariano RodríguezIgnacio López
Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T B Drüeke
Mar 12, 2004·Nephrology·Tadao AkizawaEriko Kinugasa
Feb 15, 2001·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·P Jernigan, D L Andress
Aug 31, 2002·Advances in Renal Replacement Therapy·J Wesley PikeNirupama K Shevde
Aug 31, 2002·Advances in Renal Replacement Therapy·George Kim, Stuart M Sprague
Aug 31, 2002·Advances in Renal Replacement Therapy·Olafur S Indridason, L Darryl Quarles
Nov 10, 2000·Advances in Renal Replacement Therapy·R Sadler
Oct 26, 2006·The Annals of Pharmacotherapy·Vincent C Dennis, Guy L Albertson
Feb 10, 2006·Journal of the American Society of Nephrology : JASN·Ignacio LopezMariano Rodriguez
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Glenn M ChertowUNKNOWN CONTROL Investigators
Dec 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Tilman B Drüeke, Eberhard Ritz
Mar 4, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·T C BondMahesh Krishnan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.