Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model

ACS Omega
Yinhui LiMan Shing Wong

Abstract

We report herein an investigation of carbazole-based cyanine, (E)-4-(2-(9-(2-(2-methoxyethoxy)ethyl)-9H-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide (SLM), as an effective theranostic agent for Alzheimer's disease (AD). This cyanine exhibited desirable multifunctional and biological properties, including amyloid-β (Aβ)-oligomerization inhibition, blood-brain barrier permeability, low neurotoxicity, neuroprotective effect against Aβ-induced toxicities, high selectivity and strong binding interactions with Aβ peptide/species, good biostability, as well as strong fluorescence enhancement upon binding to Aβ species for diagnosis and therapy of AD. This cyanine has been successfully applied to perform near-infrared in vivo imaging of Aβ species in transgenic AD mouse model. The triple transgenic AD mice intraperitoneally treated with SLM showed significant recovery of cognitive deficits. Furthermore, those SLM-treated mice exhibited a substantial decrease in both of oligomeric Aβ contents and tau proteins in their brain, which was attributed to the induction of autophagic flux. These findings demonstrated for the first time that SLM is an effective theranostic agent with in vivo efficacy for diagnosis and treatment of AD in m...Continue Reading

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Citations

Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chao PengMan Shing Wong
Nov 3, 2020·Chemistry : a European Journal·Kristina Ilina, Maged Henary
Feb 7, 2021·European Journal of Medicinal Chemistry·Daniela MalafaiaArtur M S Silva
Nov 2, 2019·Chemical Reviews·Amir AliyanAngel A Martí

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Methods Mentioned

BETA
fluorescence imaging
transgenic
Fluorescence
electrophoresis
Assay
protein assay

Software Mentioned

GraphPad Prism
Living Image
Quantity One

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