Effective therapeutic dosage of antipsychotic medications in patients with psychotic symptoms: Is there a racial difference?

BMC Research Notes
Muideen O Bakare

Abstract

Genetic make up had been known to influence pharmacokinetics and pharmacodynamics of psychotropic medications. Time separation in evolutionary trend in Africans, Orientals and Caucasians had been thought a possible explanation for the observed racial variation in activities of Cytochrome P 450 (CYP 450) enzymes, which are responsible for metabolism of psychotropic and other medications in human. Past studies on pharmacokinetics and pharmacodynamics of antipsychotic medications and socio-cultural factors influencing response to antipsychotic medications had consistently giving an inkling of possible racial difference in symptoms response to antipsychotic medications. Another growing body of evidence subscribing to possible racial difference in psychotic symptoms response to antipsychotic medications is the observed variation in antipsychotic medications prescription pattern and dosage across races and regions. Empirical observation had shown that dosage prescription pattern of antipsychotic medications in most Sub-Saharan African countries deviates from the standard prescription guidelines published for use in western parts of the world. Studies coming from the United States (U.S) had consistently reported a higher dosage of ant...Continue Reading

References

Jun 1, 1986·Culture, Medicine and Psychiatry·K M LinI M Lesser
Jun 1, 1988·Journal of Clinical Psychopharmacology·K M LinR T Rubin
Aug 1, 1983·Acta Psychiatrica Scandinavica·O O Famuyiwa
Jun 10, 2000·The Journal of Clinical Psychiatry·J T WalkupS Hansell
Jul 25, 2000·Journal of Clinical Pharmacy and Therapeutics·N PoolsupT L Knight
Oct 12, 2001·The Psychiatric Clinics of North America·K M LinV Ortiz
Nov 26, 2002·The Journal of Clinical Psychiatry·Francisco J Diaz, Jose De Leon
Apr 6, 2004·Schizophrenia Research·Lesley M ArnoldJenni E Farrow
Dec 29, 2005·Journal of Child and Adolescent Psychopharmacology·Nick C PatelStephen M Strakowski
May 24, 2007·International Clinical Psychopharmacology·Corrado BarbuiLuigi Grassi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here