Effective treatment for sensitive skin: 4-t-butylcyclohexanol and licochalcone A

Journal of the European Academy of Dermatology and Venereology : JEADV
M SulzbergerE Grönniger

Abstract

More than 50% of adults report to suffer from sensitive skin. This common condition is characterized by subjective sensations such as prickling, burning, skin tightness or pruritus, and is often accompanied by objective symptoms like inflammation and erythema. The objective of this study was to develop an active ingredient concept for the treatment of sensitive skin. We tested compounds regarding their potential to (i) decrease the release of proinflammatory mediators, which among others induce erythema and (ii) counteract the hyperresponsiveness of nerve fibres and, thus, exert effects on cutaneous neurosensory dysfunction. 4-t-butylcyclohexanol, licochalcone A and acetyl dipeptide-1 cetyl ester were analysed in vitro regarding their potential to (i) decrease the release of PGE2 and activation of NFκB and to (ii) inhibit TRPV1 activation or the release of neuronal CGRP. To assess subjective and objective symptoms of skin sensitivity in vivo, two controlled, single-blind, randomized studies were conducted with 4-t-butylcyclohexanol and the combination with licochalcone A. In vitro, 4-t-butylcyclohexanol significantly reduced TRPV1 activation, while acetyl dipeptide-1 cetyl ester had no effect on receptor activation. Licochalcon...Continue Reading

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Citations

Nov 25, 2016·International Journal of Cosmetic Science·S HettwerB Obermayer
Jan 12, 2017·Cutaneous and Ocular Toxicology·Douglas M FrederickAnnahita Ghassemi
Aug 14, 2020·The Journal of Dermatological Treatment·Katerina BakirtziDemetrios Ioannides
Jul 28, 2020·Journal of Cosmetic Dermatology·Yuanjin ZhangLi He
Jun 6, 2019·Frontiers in Medicine·Matthieu Talagas, Laurent Misery
Feb 13, 2020·Biomedicines·Julia HoffmannUte Wölfle
Jun 4, 2019·Frontiers in Medicine·Miranda A Farage
Nov 7, 2019·Administration and Policy in Mental Health·Gary R Bond, Robert E Drake
Feb 25, 2021·Journal of Cosmetic Dermatology·Daniel Morgado-CarrascoJaime Piquero-Casals
Aug 29, 2021·Pharmaceuticals·Diana I S P ResendeIsabel Filipa Almeida

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