Effective Treatment of Chronic Proliferative Cholangitis by Local Gentamicin Infusion in Rabbits

BioMed Research International
Qin YangQiuwei Pan

Abstract

Hepatolithiasis is highly prevalent in East Asia characterized by the presence of gallstones in the biliary ducts of the liver. Surgical resection is the potentially curative treatment but bears a high risk of stone recurrence and biliary restenosis. This is closely related to the universal presence of chronic proliferative cholangitis (CPC) in the majority of patients. Recent evidence has indicated the association of bacterial infection with the development of CPC in hepatolithiasis. Thus, this study aims to investigate the feasibility and efficacy of local infusion of gentamicin (an antibiotic) for the treatment of CPC in a rabbit model. The rabbit CPC model was established based on previously published protocols. Bile duct samples were collected from gentamicin-treated or control animals for pathological and molecular characterization. Histologically, the hyperplasia of biliary epithelium and submucosal glands were inhibited and the thickness of the bile duct wall was significantly decreased after gentamicin therapy. Consistently, the percentage of proliferating cells marked by ki67 was significantly reduced by the treatment. More importantly, this treatment inhibited interleukin 2 production, an essential inflammatory cytok...Continue Reading

References

Aug 5, 2000·American Journal of Infection Control·S Sheen-ChenT Lee
Aug 16, 2000·Vascular Medicine·A Ehsan, M J Mann
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N HayashiM Monden
Feb 14, 2002·The Journal of Surgical Research·Masanori YoshidaYoshio Yamaoka
Sep 25, 2003·Journal of Hepato-biliary-pancreatic Surgery·Seon-Mee ParkYong-Hyun Park
Dec 23, 2003·The American Journal of Gastroenterology·Min-Ho HuangChiu-Kuei Nien
Nov 27, 2008·Journal of Gastroenterology and Hepatology·Fu-Yu LiNing Li
Aug 10, 2013·Journal of Gastroenterology and Hepatology·Rohyun SungSeon Mee Park
Jan 7, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A GuglielmiC Iacono
May 16, 2014·Journal of Hepato-biliary-pancreatic Sciences·Yutaka SuzukiMasanori Sugiyama
Sep 4, 2015·World Journal of Surgery·Gennaro ClementeFelice Giuliante
Oct 18, 2015·Lipids in Health and Disease·Susumu Tazuma, Yasuni Nakanuma
Jan 6, 2016·World Journal of Gastroenterology : WJG·Hyo Jung KimYoung-Tae Bak
Oct 19, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Long PengWeidong Xiao
Jan 4, 2017·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Shangdong LvWenlong Zhang
Feb 7, 2017·Gastroenterology Research and Practice·Xi RanBaojin Ma

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Methods Mentioned

BETA
dissection
enzyme-linked immunosorbent assay
surgical resection

Software Mentioned

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