PMID: 8976661Sep 1, 1996Paper

Effective treatment of painful bone crises in type I gaucher's disease with high dose prednisolone

Archives of Disease in Childhood
I J CohenR Zaizov

Abstract

In type I Gaucher's disease, episodes of severe disabling bone pain, the so called bone crises, may be resistant to all analgesics, including narcotics. The demonstration of subperiosteal oedema on magnetic resonance imaging (MRI) led to an attempt to use steroids to relieve the oedema and thereby the pain. On eight occasions, five patients with documented bone crises received conventional dose steroids (20 mg/m2/day) with considerable shortening of the attacks. On six occasions five further patients received high dose methylprednisolone (30 mg/kg intravenously or 1 g/m2 orally daily for two days), which was followed by oral prednisone for three to five days on the last four occasions. In this later group, pain relief was evident within several hours. Three treatments were given on an ambulatory basis. The MRI scan of one of these patients showed no subperiosteal fluid collection five days after high dose steroids had been started, and on subsequent x ray examination, there was no periosteal elevation. This treatment should be considered in cases of Gaucher's disease with bone crises.

References

Oct 1, 1992·American Journal of Surgery·I J CohenR Zaizov
Apr 1, 1991·The Journal of Bone and Joint Surgery. American Volume·K KatzE Lubin
Apr 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P Siegel, R K Puri
Aug 1, 1990·American Journal of Medical Genetics·E H KolodnyM Horowitz
Jul 1, 1990·The Biochemical Journal·J M AertsA W Schram
Apr 1, 1990·Clinical Radiology·B J CreminJ Goldblatt
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S BeissertM Krönke
Oct 1, 1986·Radiology·A LanirM E Clouse
Sep 1, 1971·Clinical Orthopaedics and Related Research·F R Noyes, W S Smith
Dec 1, 1970·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·G B Greenfield
Nov 1, 1981·The Journal of Clinical Investigation·I GeryJ A Barranger
May 1, 1993·The American Journal of the Medical Sciences·E P Frenkel
Mar 17, 1994·The New England Journal of Medicine·T C GriffinG R Buchanan
Jul 1, 1993·Pediatric Hematology and Oncology·I J Cohen

❮ Previous
Next ❯

Citations

Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Aabha Nagral
Jul 10, 2012·European Journal of Pediatrics·Paige KaplanIan J Cohen
Mar 14, 1998·Baillière's Clinical Haematology·D ElsteinH J Mankin
Aug 22, 2006·Molecular Genetics and Metabolism·Joseph Martin Alisky
Mar 29, 2021·Neuroscience and Biobehavioral Reviews·Christine B SiebergIgor Elman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.