Effective treatment of verapamil intoxication with 4-aminopyridine in the cat

The Journal of Clinical Investigation
S AgostonD R Uges

Abstract

To study the value of 4-aminopyridine as an antidote to verapamil intoxication, we subjected 12 adult cats to verapamil poisoning by administering doses of 4.0-25.0 mg/kg verapamil by intravenous infusion. Six animals were given 4-aminopyridine 2 X 0.5 mg/kg i.v. after the verapamil infusion was stopped and the other six animals (the control group) were not. Verapamil caused profound cardiovascular depression and also partial neuromuscular block, both of which were completely reversed by 4-aminopyridine within 50 min, in spite of extremely high serum verapamil concentrations (ranging between 3,700 and 13,500 ng/ml). The six animals that received 4-aminopyridine survived the verapamil intoxication, whereas four of the six animals in the control group died. The results suggest that 4-aminopyridine may be useful in the treatment of verapamil intoxication.

References

Aug 1, 1978·The Journal of Pharmacy and Pharmacology·H A Al-HaboubiA O Savage
Dec 1, 1978·British Journal of Pharmacology·P Illes, S Thesleff
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Jul 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·T Yanagisawa, N Taira
Mar 16, 1979·Pflügers Archiv : European journal of physiology·H FolgeringS Agoston
Jun 18, 1977·Archives of Toxicology·H P GelbkeG Schmidt
Oct 21, 1978·British Medical Journal·C M Perkins
Jan 1, 1977·Journal of Neural Transmission·E S ViziF F Foldes
Jan 1, 1976·Biophysical Journal·J Z YehT Narahashi
Jan 31, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
Jan 31, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B Katz, R Miledi
May 1, 1983·Canadian Anaesthetists' Society Journal·B J KraynackJ Gintautas
Jan 28, 1982·The New England Journal of Medicine·V T HattoriD Peter
Jan 1, 1982·Clinical and Experimental Pharmacology & Physiology·S AgostonA O Savage
Jan 1, 1981·International Journal of Cardiology·P ImmonenE Waris

❮ Previous
Next ❯

Citations

Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M P RamoG Grupp
May 18, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Andis Graudins, Kathy Ka Ling Wong
Jul 12, 2012·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Andrew M KingAnthony F Pizon
Jul 19, 2012·Clinical Neuropharmacology·Saam SedehizadehPaul Maddison
Feb 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C K StoneR B Low
Aug 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·S I KouryS H Thomas
Jun 1, 1986·The Journal of Clinical Investigation·R GayS Goldman
Oct 7, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·M St-OngeR Blais
Feb 1, 1992·The American Journal of the Medical Sciences·D MacDonald, P C Alguire
Mar 3, 2012·The Veterinary Clinics of North America. Small Animal Practice·Cristine L Hayes, Michael Knight
Jul 21, 2011·Journal of Molecular and Cellular Cardiology·Zachary C BerwickJohnathan D Tune
Jul 12, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Carmen Espejo, Xavier Montalban
Nov 21, 2007·Journal of Clinical Pharmacy and Therapeutics·B WilffertJ R B J Brouwers
Jun 4, 2013·Basic & Clinical Pharmacology & Toxicology·Sule OzbilginAli Gunerli
Jul 1, 1995·The American Journal of Emergency Medicine·L ProanoR Y Wang
Oct 1, 1993·The American Journal of Medicine·C A HoferM F Tenholder
Oct 1, 1987·The American Journal of Cardiology·A T Jakubowski, H F Mizgala
Mar 1, 1995·Annals of Emergency Medicine·C K StoneR Carroll
Jun 11, 1998·Emergency Medicine Clinics of North America·M B Miller
Mar 1, 1994·Annals of Emergency Medicine·M C PlewaA B Wolfson
May 1, 1985·Human Toxicology·P M ter WeeS van der Geest
Jan 22, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Steven D Salhanick, Michael W Shannon
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·W WananukulP R Pentel
Dec 14, 2004·CNS Drug Reviews·Keith C Hayes
Nov 1, 1992·The Annals of Pharmacotherapy·S M WatlingR A Stiller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.