Effective use of JC virus PCR for diagnosis of progressive multifocal leukoencephalopathy

Journal of Medical Microbiology
Yihong WangQinfang Qian

Abstract

In a retrospective review of data from 168 patients with suspected progressive multifocal leukoencephalopathy (PML) between 1996 and 2006, JC virus (JCV) PCR on cerebrospinal fluid (CSF) samples was positive only in human immunodeficiency virus (HIV)-infected patients with low CD4 cell counts and in severely immunocompromised patients with radiographic lesions consistent with PML or infectious processes generally. Of note, one HIV patient with a very low CD4 cell count had a positive JCV PCR despite a normal magnetic resonance imaging exam. We concluded that JCV PCR testing on CSF specimens should therefore be targeted to these high-risk patients.

References

Nov 1, 1988·Radiology·W L OlsenD Norman
Jun 1, 1995·Pathology, Research and Practice·A J MartínezJ Cervós-Navarro
Apr 8, 1998·Journal of Neurovirology·J R BergerM Whiteman
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Y W TangD H Persing

❮ Previous
Next ❯

Citations

Nov 16, 2010·AIDS·Paul ShapshakJohn T Sinnott
Oct 11, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Julia KeithRoy Baskind
May 1, 2010·Future Virology·A Sami SaribasMahmut Safak
Apr 5, 2016·Annals of Clinical and Translational Neurology·Nicolien M van der KolkBrigit A de Jong
Nov 26, 2009·Neurologic Clinics·Elyse J SingerAndrew Levine
Apr 5, 2013·HIV Medicine·J BashfordM Atkins
Feb 16, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·J KeithZ Ghorab
Mar 19, 2014·The Pediatric Infectious Disease Journal·Hayden SchwenkAsim Ahmed
Jul 20, 2011·Molecular Diagnosis & Therapy·Sathish SankarGopalan Sridharan

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.