Effective use of TNF antagonists

Arthritis Research & Therapy
David Yocum

Abstract

Tumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved functional outcomes in patients with rheumatoid arthritis (RA). RA is a progressive disease in which structural joint damage can continue to develop even in the face of symptomatic relief. Before the introduction of biologic agents, the management of RA involved the use of disease-modifying antirheumatic drugs (DMARDs) early in the course of disease. This focus on early treatment, combined with the availability of the anti-TNF agents, has contributed to a shift in treatment paradigms favoring the early and timely use of DMARDs with biologic therapies. Improvement in symptom control does not always equate to a reduction in disease progression or disability. With the emergence of structure-related outcome measures as the primary means for assessing the effectiveness of antirheumatic agents, the regular use of X-rays is recommended for the continued monitoring and evaluation of patients. In addition to the control of symptoms and improvement in physical function, a reduction in erosions and joint-space narrowing should be considered among the goals of therapy, leading to a better quality of life. Adherence to therapy is an impo...Continue Reading

References

Nov 30, 2000·The New England Journal of Medicine·J M BathonB K Finck
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Jan 6, 2001·Arthritis and Rheumatism·F Wolfe
Jun 9, 2001·Rheumatic Diseases Clinics of North America·J R Kirwan
Jan 5, 2002·Arthritis and Rheumatism·J B WongG Singh
Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
Aug 15, 2002·Annals of the Rheumatic Diseases·P GeborekUNKNOWN South Swedish Arthritis Treatment Group

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Citations

Aug 30, 2005·Annals of the New York Academy of Sciences·Stanley M Naguwa
Apr 1, 2007·EcoSal Plus·Roberta Leonardi, Suzanne Jackowski
Dec 28, 2010·Trends in Pharmacological Sciences·Emanuela Esposito, Salvatore Cuzzocrea

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Methods Mentioned

BETA
X-ray
ESR

Software Mentioned

Centocor

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