Effective vancomycin concentrations in children: a cross-sectional study

Einstein
Geisa Cristina da Silva AlvesCristina Sanches

Abstract

Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour interval between each withdrawal. Ten pediatric patients with median age of 5.5 years and interquartile range (IQR) of 3.2-9.0 years, median weight of 21kg (IQR: 15.5-24.0kg) and median height of 112.5cm (IQR: 95-133cm), were included. Only one child achieved trough concentrations between 10µg/mL and 15µg/mL. The empirical use of vancomycin in the children studied did not achieve the therapeutic pharmacokinetic/pharmacodynamic target for minimum inhibitory concentration of 1µg/mL.

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Aug 5, 2017·European Journal of Clinical Pharmacology·Geisa Cristina da Silva AlvesCristina Sanches

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Citations

Apr 30, 2021·International Journal of Clinical Pharmacy·Tatjana Van Der HeggenPieter A J G De Cock

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Methods Mentioned

BETA
pharmacotherapy

Software Mentioned

ChemStation for LC 3D systems
BestDose
Excel
BestDose [UNK]

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