Effectiveness and clinical implications of the use of topical antibiotics in regenerative endodontic procedures: a review

International Endodontic Journal
P Montero-MirallesJ J Segura-Egea

Abstract

Regenerative endodontic procedures (REPs) are biologically based procedures planned to replace damaged tissues, including dentinee and root structures, as well as cells of the pulp-dentine complex. Effective sterilization of the root canal is essential in REPs, and antibiotics have been widely used to disinfect root canals. The aim of this paper was to review the scientific literature on (i) Effectiveness of antibiotics used in REPs against bacteria implicated in endodontic disease; (ii) Scientific evidence supporting the use of topical antibiotics in REPs; (iii) Clinical implications of the use of antibiotics in REPs and the possible side effects; (iv) Effect of antibiotics on dental pulp stem cells; and (v) Ongoing research on the use of antibiotics in REPs. Antibiotics used in REPs are effective against bacteria implicated in endodontic infections. Triple antibiotic pastes with minocycline attain complete disinfection of immature teeth with necrotic pulps, without affecting SCAP. Experimental studies carried out in dogs support the use of antibiotics in REPs. Clinical studies report high success rates of RET using antibiotics as intracanal dressings. However, tooth discolouration is an important side effect of the use of TAP...Continue Reading

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Citations

Oct 1, 2020·Journal of Applied Oral Science : Revista FOB·Andrea Cardoso PereiraAdriana DE-Jesus-Soares
Nov 24, 2020·Primary Dental Journal·Adam S KharchiShalini Kanagasingam
Nov 29, 2020·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Julia Knabben BrogniThais Mageste Duque
Nov 28, 2020·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M E C ElfrinkJ S J Veerkamp
Apr 18, 2021·Journal of Endodontics·Carmen María Ferrer-LuqueMatilde Ruiz-Linares
Nov 28, 2018·Journal of Endodontics·Gisele FariaMario Tanomaru Filho

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