Effectiveness and infant acceptance of the Rx medibottle versus the oral syringe

Pharmacotherapy
D M KrausS A Freels

Abstract

To compare the effectiveness and infant acceptance of drug delivery of the Rx medibottle with the standard oral syringe. Prospective open-label, randomized, crossover clinical study. General pediatric outpatient clinic at an urban university. Thirty healthy, bottle-fed infants, aged 2-14 months, receiving routine vaccinations. Each infant received a single dose of acetaminophen (Tempra syrup), with one-half delivered by the Rx medibottle and one-half delivered with an oral syringe. Three raters independently evaluated effectiveness and infant acceptance of each drug-delivery device. Effectiveness was based on the percentage of infants receiving 100% of the intended dose. Infant acceptance was scored using a validated infant medication acceptance scale (MAS, 10 = highest level). Significantly more infants received 100% of the intended dose with the Rx medibottle (93.3%) than with the oral syringe (56.7%, p=0.0074). Infants had a significantly higher mean MAS score when using the Rx medibottle (8.3+/-1.8 vs 7.3+/-1.7, p=0.002). In addition, a significantly higher percentage had ideal MAS scores of 9 or above with the Rx medibottle (73%) compared with the oral syringe (17%, p=0.0001). The Rx medibottle was more effective and had a...Continue Reading

References

Aug 1, 1980·American Pharmacy·M D Kimminau
Aug 1, 1994·The Pediatric Infectious Disease Journal·R DaganZ Liss
Sep 1, 1997·Pediatrics·S R McMahonR C Bay
Jun 29, 1999·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·D M KrausP R Hannon

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Citations

Aug 8, 2015·Clinical Pharmacokinetics·Matthew W LinakisCatherine M T Sherwin
Jul 15, 2015·Expert Opinion on Drug Delivery·Felipe L LopezMine Orlu Gul
Aug 14, 2012·International Journal of Pharmaceutics·Gesine Winzenburg, Sabine Desset-Brèthes
Jun 11, 2015·Journal of Cognitive Neuroscience·Alexandra WoolgarAnina N Rich
Jan 14, 2017·Environmental Science & Technology·Dandan CaoGuibin Jiang
Nov 21, 2020·Drug Discovery Today·Catherine TuleuFabrice Ruiz
Feb 2, 2021·International Journal of Pharmaceutics·Kwadwo Amanor MfoafoHossein Omidian

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