Effectiveness and morbidity associated with reirradiation in conservative salvage management of recurrent soft-tissue sarcoma

International Journal of Radiation Oncology, Biology, Physics
Daniel J IndelicatoRobert A Zlotecki

Abstract

The management of isolated local recurrence of soft-tissue sarcoma is therapeutically complex, and functional conservative management is preferable to radical or amputative salvage surgery. This study reviews the University of Florida experience using conservative resection and reirradiation to manage isolated local recurrences of soft-tissue sarcoma. Between 1976 and 2005, a total of 14 patients who underwent primary conservative resection and irradiation developed isolated local recurrence and were managed with salvage conservative resection and reirradiation. Of the patients treated, 3 had tumors of the distal extremity, 8 had tumors of the proximal extremity, and 3 had tumors of the trunk. At the time of recurrence, 64% of tumors were greater than 5 cm and 79% were high grade. In combination with gross total resection, 13 of 14 patients received external beam radiotherapy with or without brachytherapy, and 1 patient was treated with brachytherapy alone. Two patients received chemotherapy. The median follow-up was 30 months, and no living patients were lost during follow-up. From retreatment, the 5-year actuarial overall survival, cause-specific survival, and local control rates were 40%, 40%, and 18% respectively. There was...Continue Reading

References

Nov 1, 1975·Annals of Surgery·M H ShiuJ G Fortner
Feb 1, 1992·The British Journal of Radiology·J D GrahamC L Harmer
May 1, 1992·Archives of Surgery·S SingerT J Eberlein
Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M J ZelefskyM F Brennan
Feb 1, 1986·Cancer·C P KarakousisR M Krishnamsetty
Apr 1, 1984·American Journal of Surgery·W C WoodK Proppe
Jul 1, 1982·Annals of Surgery·A E GiulianoD L Morton
May 16, 2001·Annals of Surgical Oncology·R C RamanathanJ M Thomas
Oct 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P PopovM Tarkkanen
Dec 14, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laurence Moureau-ZabottoMartine Delannes
Jan 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Mylin A TorresGunar K Zagars
Jul 4, 2007·International Journal of Radiation Oncology, Biology, Physics·Damien C WeberGudrun Goitein

❮ Previous
Next ❯

Citations

Oct 29, 2010·Sarcoma·Brendan PrendergastDaniel J Indelicato
Aug 29, 2013·TheScientificWorldJournal·Lukas M NystromC Parker Gibbs
Oct 1, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ModestoM Delannes
Apr 22, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A ModestoM Delannes
Apr 1, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Maximilian RudertBarbara Röper
Dec 6, 2011·Critical Reviews in Oncology/hematology·Juliette ThariatJean-Léon Lagrange
Jul 23, 2013·Journal of Medical Imaging and Radiation Oncology·Michael K Y NgSamuel Y K Ngan
Sep 9, 2015·Sarcoma·Christopher L TinkleAlexander R Gottschalk
Aug 21, 2016·The Surgical Clinics of North America·Whitney M Guerrero, Jeremiah L Deneve
Jan 1, 2015·Rare Cancers and Therapy·Samia ArifiNabil Ismaili
Jul 30, 2020·Cancers·Mateusz Jacek SpałekPiotr Rutkowski
Nov 11, 2021·American Journal of Clinical Oncology·Erica L BraschiRobert A Zlotecki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.