Effectiveness and safety of abatacept in elderly patients with rheumatoid arthritis enrolled in the French Society of Rheumatology's ORA registry

Rheumatology
Clément LahayeFrench Society of Rheumatology

Abstract

To study the effect of age on the risk-benefit balance of abatacept in RA. Data from the French orencia and RA registry, including a 2-year follow-up, were used to compare the effectiveness and safety of abatacept according to age. Among the 1017 patients, 103 were very elderly (⩾75 years), 215 elderly (65-74), 406 intermediate aged (50-64) and 293 very young (<50). At baseline, elderly and very elderly patients had longer disease duration, higher CRP levels and higher disease activity. These age groups showed a lower incidence of previous anti-TNF therapy and less common concomitant use of DMARDs, but a similar use of corticosteroid therapy. After adjusting for disease duration, RF/ACPA positivity, use of DMARDs or corticosteroids and previous anti-TNF treatment, the EULAR response (good or moderate) and the remission rate were not significantly different between the four age groups. At 6 months, the very elderly had a significantly lower likelihood of a good response than the very young (odds ratio = 0.15, 95% CI: 0.03, 0.68). The decrease in DAS28-ESR over the 24-month follow-up period did not differ by age. Increasing age was associated with a higher rate of discontinuation for adverse events, especially severe infections (...Continue Reading

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Citations

Apr 20, 2017·Current Opinion in Rheumatology·Fabiola AtzeniPiercarlo Sarzi-Puttini
Jun 2, 2017·Nature Reviews. Rheumatology·Elena NikiphorouKimme L Hyrich
Jun 14, 2017·Drugs·Hannah A Blair, Emma D Deeks
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Oct 16, 2021·Diabetes/metabolism Research and Reviews·Valeria PozzilliValentina Tomassini
Nov 19, 2021·Modern Rheumatology·Takahiko Sugihara

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