Effectiveness and safety of community-based treatment with sofosbuvir plus ribavirin for elderly patients with genotype 2 chronic hepatitis C

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Masanori AtsukawaKatsuhiko Iwakiri

Abstract

The aim of this study was to clarify the effectiveness and safety of sofosbuvir/ribavirin therapy for elderly patients with genotype 2-infected chronic hepatitis C (CHC) in Japan. A multicenter, retrospective study evaluated the effectiveness and safety of sofosbuvir/ribavirin based on real-world clinical data. The subjects consisted of 270 patients, 47.0% of whom were aged ≥65 years. The sustained virological response rates in patients aged <65 and ≥65 years were 98.6% and 95.3%, respectively. Hemoglobin levels decreased during treatment due to ribavirin-related hemolysis, and were significantly lower in patients aged ≥65 years than those aged <65 years at all time-points. A reduction in ribavirin dose was necessary in 31.0% (26/84) of patients with hemoglobin levels <13.0g/dL and in 70.7% (39/127) of those aged >65 years. Although the most frequent adverse event was anemia, no patients discontinued the use of either ribavirin or sofosbuvir. The incidence of ribavirin-related anemia in patients aged ≥65 years was 34.6% and significantly higher compared with that in patients aged <65 years (2.8%). Treatment with sofosbuvir/ribavirin for genotype 2-infected CHC was effective and safe even for elderly patients, although the incid...Continue Reading

Citations

Sep 2, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Takehiro AkahaneNamiki Izumi
Nov 30, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masanori AtsukawaKatsuhiko Iwakiri
Jun 28, 2019·Journal of Viral Hepatitis·Rosanna VillaniGaetano Serviddio
Dec 29, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Asahiro MorishitaTsutomu Masaki
Oct 28, 2019·Journal of the American Geriatrics Society·Calvin Q PanPavani Garlapati
Apr 30, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Marcus M MückeJohannes Vermehren
May 26, 2018·Journal of the American Geriatrics Society·Chiara MazzarelliMary D Cannon
Oct 10, 2020·World Journal of Hepatology·Hideyuki TamaiKatsuhiko Higashi
Mar 12, 2021·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Masanori AtsukawaKatsuhiko Iwakiri

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