Effectiveness and safety of dabigatran therapy in daily-care patients with atrial fibrillation. Results from the Dresden NOAC Registry

Thrombosis and Haemostasis
Jan Beyer-WestendorfNorbert Weiss

Abstract

The effectiveness and safety of dabigatran for stroke prevention in atrial fibrillation (SPAF) demonstrated in RE-LY needs to be confirmed in daily care. To evaluate treatment persistence, effectiveness and safety of dabigatran therapy in SPAF patients in daily care, we used data from an ongoing, prospective, non-interventional registry of more than 2,500 patients on novel oral anticoagulants in daily care. Between October 1, 2011 and February 28, 2013, a total of 341 SPAF patients receiving dabigatran were enrolled. The combined endpoint of stroke/transient ischaemic attack/systemic embolism occurred at a rate of 2.93/100 patient-years in the intention-to-treat analysis (95%-CI 1.6-4.9) and at 1.9/100 patient-years in the on treatment analysis (events within three days after last intake). On-treatment rates were higher in patients selected for 110 mg dabigatran (n=183) BID compared to the 158 patients selected for 150 mg BID (2.88 [95% CI 1.16- 5.93] vs 0.86/100 patient-years [95% CI 0.10, 3.12]). On treatment, major bleeding occurred at a rate of 2.3/100 patient-years and numerically more often in patients receiving the 110 mg BID dose compared to the 150 mg BID dose (2.9 vs 1.7/100 patient-years). Dabigatran treatment discon...Continue Reading

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References

Feb 11, 2005·JAMA : the Journal of the American Medical Association·Gregory W AlbersUNKNOWN SPORTIF Executive Steering Committee for the SPORTIF V Investigators
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Oct 21, 2010·Circulation. Cardiovascular Quality and Outcomes·Margaret C FangDaniel E Singer
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Oct 24, 2012·Archives of Internal Medicine·Tara GomesDavid N Juurlink
Nov 28, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tara GomesDavid N Juurlink
May 7, 2013·BMJ Open·Rikke SørensenMorten Lock Hansen
Aug 8, 2013·Circulation. Cardiovascular Quality and Outcomes·Martin ZalesakHerman Sanchez
Nov 21, 2013·The New England Journal of Medicine·Robert P GiuglianoUNKNOWN ENGAGE AF-TIMI 48 Investigators
Apr 5, 2014·British Journal of Clinical Pharmacology·Jan Beyer-WestendorfNorbert Weiss
Sep 2, 2014·Current Pharmaceutical Design·Deirdre A LaneGregory Y H Lip

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Citations

Nov 18, 2015·Expert Review of Hematology·Maria Teresa Sartori, Paolo Prandoni
Nov 13, 2015·Expert Opinion on Pharmacotherapy·Mikhail S Dzeshka, Gregory Y H Lip
Nov 29, 2015·European Journal of Clinical Pharmacology·Tomas ForslundPaul Hjemdahl
Oct 28, 2015·Current Medical Research and Opinion·Paolo Prandoni
Feb 3, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jan Beyer-WestendorfThomas Evers
Nov 1, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Steen HustedWillemijn J Comuth
Aug 8, 2015·Thrombosis and Haemostasis·Carlos MartinezSaul Benedict Freedman
Apr 17, 2015·Thrombosis and Haemostasis·John W Eikelboom, Jeffrey I Weitz
May 6, 2015·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Sebastian WerthJan Beyer-Westendorf
May 10, 2016·Expert Opinion on Drug Discovery·Martin Feuring, Joanne van Ryn
Feb 27, 2016·Thrombosis and Haemostasis·Jan Beyer-WestendorfSandra Marten
Jul 1, 2016·Thrombosis and Haemostasis·Jacqueline M L HaltonLesley G Mitchell
Sep 1, 2016·Herzschrittmachertherapie & Elektrophysiologie·Thomas Maria HelmsJohann Christoph Geller
Sep 15, 2016·Thrombosis and Haemostasis·Jan Beyer-WestendorfSally Tamayo
Sep 28, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N FeltgenJ Koscielny
Sep 2, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hein HeidbuchelPaulus Kirchhof
Feb 20, 2016·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dagmar KubitzaFrank Misselwitz
Sep 1, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Alpesh Amin, Joel C Marrs
Feb 16, 2017·Blood Reviews·Alessandro Di MinnoDamiano Baldassarre
Jan 31, 2017·International Journal of Cardiology·Maria Cristina VedovatiCecilia Becattini
Feb 22, 2017·Chest·Yan XuUNKNOWN Bleeding Effected by Direct Oral Anticoagulants (BLED-AC) Study Group
Jul 15, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Ludovic DrouetJan Purrucker
Mar 24, 2018·Current Opinion in Nephrology and Hypertension·Justin Ashley, Manish M Sood
Feb 3, 2016·Therapeutic Advances in Drug Safety·Esa Y H ChenJenni Ilomäki
Feb 1, 2018·Current Medical Research and Opinion·Emilio Márquez-ContrerasUNKNOWN Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA)
Sep 28, 2018·Expert Opinion on Drug Safety·Paolo VerdecchiaGiancarlo Agnelli
May 6, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Maureen A SmytheJohn Fanikos
Jul 25, 2019·Current Medical Research and Opinion·Begoña Navarro-AlmenzarSergio Manzano-Fernández

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Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
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