Effectiveness and safety of methylphenidate in adult attention deficit hyperactivity disorder in patients with epilepsy: an open treatment trial

Epilepsy & Behavior : E&B
C M van der Feltz-Cornelis, Albert P Aldenkamp

Abstract

The purpose of this study was to evaluate the effectiveness and safety of methylphenidate treatment in epilepsy patients with comorbid adult attention deficit hyperactivity disorder (ADHD). Six of 156 consecutive patients attending a tertiary epilepsy clinic for diagnostic evaluation of new seizures, 3 patients with epilepsy and 3 patients with psychogenic non-epileptic seizures, were diagnosed with comorbid adult ADHD. These 6 patients entered an open trial of methylphenidate 10 mg twice daily. Clinical improvement was assessed at 6 weeks of follow-up. Both groups showed clinical improvement of ADHD symptoms during treatment. None of the patients with comorbid epilepsy experienced adverse effects on seizure control or antiepileptic drug use. In this open trial methylphenidate was safely used in patients with epilepsy and adult ADHD. It was effective against adult ADHD, and there were no adverse effects on seizure severity and frequency. A randomized study is needed to further establish effectiveness and safety.

References

Sep 1, 1989·American Journal of Diseases of Children·H FeldmanJ Teodori
Apr 30, 1999·The Journal of Nervous and Mental Disease·C M van der Feltz-Cornelis
Aug 10, 2002·Seminars in Neurology·Jorge J Asconapé
May 2, 2003·Psychosomatics·Sirpa A Tavakoli, Ondria C Gleason
Jun 26, 2003·Epilepsia·Albert P AldenkampRianne Reijs
Jul 9, 2004·Archives of General Psychiatry·Dale C HesdorfferW Allen Hauser

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Citations

May 31, 2011·Expert Opinion on Drug Safety·Sherifa Ahmad Hamed
Dec 22, 2007·Expert Opinion on Investigational Drugs·Lourival Baptista-NetoJoseph Gonzalez-Heydrich
Oct 17, 2007·The Psychiatric Clinics of North America·Michael J Marcangelo, Fred Ovsiew
Jun 27, 2007·Developmental Medicine and Child Neurology·Joachim F WernickeDavid Dunn
Aug 2, 2007·Primary Care·Sreenivas Katragadda, Howard Schubiner
Nov 29, 2015·Neurologic Clinics·Beth A Leeman-Markowski, Steven C Schachter
Sep 25, 2016·Journal of Attention Disorders·Johanne Telnes InstanesJan Haavik
Mar 27, 2010·Arquivos de neuro-psiquiatria·Julio A S Koneski, Erasmo B Casella
Oct 11, 2017·Epilepsia·Jesse AdamsKimford J Meador
Feb 25, 2018·Neurology·Kelsey K WiggsBrian M D'Onofrio
Dec 29, 2020·Epilepsy & Behavior : E&B·Beth A Leeman-MarkowskiKimford J Meador

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