Effectiveness and safety of proton pump inhibitors in infantile gastroesophageal reflux disease

The Annals of Pharmacotherapy
Tanner W Higginbotham

Abstract

To evaluate the efficacy and safety of proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD) in infants <1 year of age. A literature search was conducted through PubMed (up to December 2009), International Pharmaceutical Abstracts (1970-December 2009), and The Cochrane Library (up to December 2009) using combinations of the following key search terms: proton pump inhibitor, GERD, infant, children, pediatric, omeprazole, rabeprazole, lansoprazole, esomeprazole, and pantoprazole. Reference citations from identified articles were also reviewed. All double-blind, placebo-controlled trials published in English that evaluated the safety and efficacy of PPIs in infants with GERD were included in this review. Trials involving children older than 12 months were not included. GERD is a source of pain and discomfort in adults; yet, in infants, symptoms that are thought to be indicative of painful stimuli have no clear cause-and-effect relationship with infant GERD. PPIs are beneficial in relieving symptoms of GERD in the adult population, but their usefulness in decreasing GERD-associated behaviors in infants is still questionable, despite a large increase in PPI prescribing for children <1 year of age. ...Continue Reading

Associated Clinical Trials

Feb 4, 2013·Neil Chadha

References

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Citations

Oct 16, 2013·Nature Reviews. Gastroenterology & Hepatology·Yvan Vandenplas
Jun 19, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·O MouterdeP Tounian
Aug 11, 2015·Journal of Paediatrics and Child Health·Catherine N KirbyLeon Piterman
Apr 20, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C M LootsT I Omari
Aug 6, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Peter MansellGregg D Cappon
Aug 21, 2013·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Ricardo A QuinonezShawn L Ralston
Jun 28, 2012·Journal for Specialists in Pediatric Nursing : JSPN·Madalynn NeuCassandra Marcheggiani-Howard
Apr 16, 2014·Journal of Pediatric Gastroenterology and Nutrition·Clara LootsTaher Omari
Mar 27, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Angela PaddackGresham T Richter
Jan 28, 2014·Journal of Pediatric Gastroenterology and Nutrition·Pauline De BruyneMyriam Van Winckel
Jul 19, 2012·Clinical Pharmacology and Therapeutics·V ShakhnovichG L Kearns
Oct 27, 2017·Hospital Pediatrics·Mario ReyesRicardo A Quinonez
Sep 1, 2018·The Lancet Child & Adolescent Health·James J Ashton, R Mark Beattie

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