Effectiveness and Safety of Tenofovir Disoproxil Fumarate in Chronic Hepatitis B: A 3-Year, Prospective, Real-World Study in France

Digestive Diseases and Sciences
Patrick MarcellinDominique Larrey

Abstract

Tenofovir disoproxil fumarate (TDF) demonstrated potent and sustainable antiviral efficacy and a good safety profile in patients with chronic hepatitis B (CHB) in controlled clinical trials. Real-world data are important to confirm effectiveness and safety data in patient populations encountered in routine clinical practice. This non-interventional, prospective, 36-month study included treatment-naïve and treatment-experienced patients with CHB initiating their first TDF regimen (monotherapy or combination therapy) in routine clinical practice in France. Clinical, virologic, biochemical, compliance, and safety data were collected. Data from 440 consecutive patients from 58 centers were analyzed. The majority of the cohort was male (71 %), hepatitis B "e" antigen-negative (HBeAg-) (74 %), and treatment-experienced (56 %); 11 % were aged ≥65 years; and comorbidities were reported in 39 %. After 12 months, 92 % of the overall cohort achieved virologic response (HBV DNA <69 IU/mL) which was maintained to 36 months (96 %); virologic response was achieved by >90 % of patients irrespective of HBeAg status, age, or prior treatment history. At 36 months, 77 % of patients had normal alanine aminotransferase levels. Fourteen patients lost...Continue Reading

References

Oct 8, 2004·The New England Journal of Medicine·Yun-Fan LiawUNKNOWN Cirrhosis Asian Lamivudine Multicentre Study Group
Jan 5, 2006·JAMA : the Journal of the American Medical Association·Chien-Jen ChenUNKNOWN REVEAL-HBV Study Group
Feb 24, 2006·La Presse médicale·Jean-Pierre Zarski
Mar 15, 2006·Gastroenterology·Uchenna H IloejeUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-In HBV (the REVEAL-HBV) Study Group
Jul 5, 2006·The American Journal of Gastroenterology·Gang ChenAlison A Evans
Aug 7, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uchenna H IloejeUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer-Hepatitis B Virus Study Group
Dec 5, 2008·The New England Journal of Medicine·Patrick MarcellinFranck Rousseau
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J Fontana
Jun 2, 2009·Gastroentérologie Clinique Et Biologique·UNKNOWN European Association For The Study Of The Liver
Aug 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna S F Lok, Brian J McMahon
Dec 10, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florian van BömmelThomas Berg
Jun 19, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edward A Lock
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Nov 8, 2012·European Journal of Public Health·Janet JunQing ChuRalf Reintjes
Sep 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liming WangMarc Bulterys

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Citations

Aug 28, 2016·Digestive Diseases and Sciences·Norah A Terrault
Jan 5, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Glenda GrossiPietro Lampertico
Apr 22, 2017·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Feb 11, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Maria ButiRafael Esteban
Dec 8, 2017·Journal of Korean Medical Science·Jae Young ChoeHye Ran Yang
Jun 26, 2020·Alimentary Pharmacology & Therapeutics·Pietro LamperticoUNKNOWN ReCoRd (Retrospective, Cohort, Renal, Viread) Investigators' Group
Mar 7, 2017·World Journal of Hepatology·Bircan Kayaaslan, Rahmet Guner
Nov 16, 2018·BMC Infectious Diseases·José Ángel Cuenca-GómezJoaquín Salas-Coronas
Oct 3, 2018·Expert Opinion on Pharmacotherapy·Premashis Kar, Anando Sengupta
Mar 19, 2020·Journal of Gastroenterology·Raquel Scherer de FragaSuzane Kioko Ono
Feb 23, 2021·Therapeutic Advances in Infectious Disease·Luisa RoadeMaria Buti
Jun 27, 2021·The Lancet Infectious Diseases·Wen-Juei JengYun-Fan Liaw

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Methods Mentioned

BETA
biopsy

Software Mentioned

VIREAL

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