Effectiveness and Safety of Transcatheter Closure of Perimembranous Ventricular Septal Defects in Adults

The American Journal of Cardiology
Jianming WangJian Yang

Abstract

This study was designed to determine the long-term safety and efficacy of using modified double-disk occluders for perimembranous ventricular septal defect (pmVSD) closure in adults. From January 2004 to December 2014, 337 adults with pmVSDs were treated through transcatheter intervention using 2 types of double-disk occluders; 302 patients received a symmetrical concentric pmVSD occluder, and 35 patients received an asymmetrical concentric pmVSD occluder. All patients were followed up through electrocardiography and transthoracic echocardiography until June 2015. The success rate was 100% for both procedures. During the median 71-month follow-up period, no cases of infective endocarditis, cerebrovascular accidents, heart failure, or death occurred. Two major adverse events (0.6%) were recorded: complete atrioventricular block requiring surgical treatment in one patient and severe tricuspid valvular regurgitation requiring surgical repair in another patient. Cardiac conduction block was the most common minor adverse event. The mean left ventricular (LV) end-diastolic volume decreased from 96.6 ± 23.2 ml before intervention to 86.0 ± 22.0 ml (p <0.05) at the 6-month follow-up visit. Previously enlarged LV chambers decreased to n...Continue Reading

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Citations

Jun 8, 2017·Current Opinion in Cardiology·Nao Sasaki, Leo Lopez
Apr 17, 2020·Future Cardiology·Robert J Henning
Oct 27, 2017·Current Cardiology Reports·Luis AfonsoAnirudh Penumetcha
Mar 24, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Lihong TangYumei Xue
Feb 4, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Haisong BuTianli Zhao

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