Effectiveness and safety of two different antithymocyte globulins used in induction therapy in kidney transplant recipients: A single-center experience

Clinical Transplantation
Beata StyrcAndrzej Więcek

Abstract

Antithymocyte globulin (ATG) is widely used as an induction therapy after kidney transplantation. The present study aimed to compare the effectiveness and safety of induction therapy between two ATG formulations, Grafalon (Fresenius® ) and Thymoglobulin (Sanofi® ), in kidney transplant patients. This study included 140 consecutive kidney transplant recipients, 71 treated with Grafalon and 69 treated with Thymoglobulin, in the period between February 2010 and January 2018. To optimize therapy costs, considering the periodically limited drug availability and the substantial drug waste in the case of Grafalon, Thymoglobulin induction was introduced into the immunosuppressive protocol. The ATG total dose in mg/kg of body mass [median: 5.3 (3.7-7.1) vs 8.6 (4.3-17.3); P < .001] was significantly lower in the Thymoglobulin subgroup. There were 7 (5%) graft losses and 15 (10.7%) deaths during the first 12 months, with 66.7% of deaths due to infection complications. Patients treated with Thymoglobulin were characterized by a lower absolute lymphocyte count at day 7 and during the 12 months of follow-up, compared with the Grafalon group [236 (205-267) vs 483 (372-594), respectively; P < .001]. Logistic regression analysis showed that a ...Continue Reading

References

Nov 10, 2006·The New England Journal of Medicine·Daniel C BrennanUNKNOWN Thymoglobulin Induction Study Group
Jun 15, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V PatlollaD A Mandelbrot
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Jul 24, 2013·Expert Opinion on Biological Therapy·Afshin GharekhaniHossein Khalili
Aug 6, 2013·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Federico CicoraJavier Roberti
Feb 25, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R HellemansD Abramowicz
Mar 10, 2016·Transplantation Reviews·Julio PascualMaarten Naesens

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Citations

Oct 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Guy El HelouRaymund Razonable

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