Effectiveness and safety of vedolizumab for maintenance treatment in inflammatory bowel disease-The Israeli real world experience

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Uri KopylovIris Dotan

Abstract

Several real-world experience (RWE) studies with vedolizumab (VDZ) for induction of remission in inflammatory bowel diseases (IBD) have been published; however, long-term RWE data is scarce. To describe the effectiveness and safety of VDZ in maintenance treatment of IBD. A multicenter retrospective national study. The primary outcome of was clinical response at week 52; main secondary aims included clinical remission at week 52, rates of secondary loss of response and treatment discontinuation. We included 193 (133-CD; 60-UC) patients from 9 Israeli IBD centers. At week 52, response was observed in 62/133 (46.7%) CD patients, including 28 (21%) in clinical remission; 71 (53.3%) discontinued treatment or did not respond. For UC, response at week 52 was observed in 27/60 (45%), including 20 (33%) in clinical remission; 33 (55%) discontinued treatment or did not respond. Secondary non-response by week 52 occurred in 19.4% and 23.5% of week 14 responders in CD and UC, respectively. Week 14 response was associated with treatment continuation at week 52: no predictors of secondary loss of response were identified. VDZ is safe and effective for maintenance of response and remission in IBD; week 14 response is positively associated wit...Continue Reading

Citations

Jan 27, 2019·Intestinal research·Tomohiro FukudaTakanori Kanai
Aug 19, 2020·United European Gastroenterology Journal·Nathaniel Aviv CohenNitsan Maharshak
Apr 18, 2020·Frontiers in Medicine·Joseph Meserve, Parambir Dulai
Apr 15, 2020·Alimentary Pharmacology & Therapeutics·Bella Ungar, Uri Kopylov
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Jul 20, 2021·Therapeutic Advances in Gastroenterology·Carl ErikssonUNKNOWN SWIBREG SVEAH Study Group

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