Effectiveness and tolerability of direct-acting antivirals for chronic hepatitis C patients in a Southern state of Brazil

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Vinicius L FerreiraRoberto Pontarolo

Abstract

This study aimed to evaluate the clinical effectiveness in terms of sustained virological response and tolerability of available second generation direct-acting antivirals in Brazilian patients. This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus, regardless of virus genotype, fibrosis stage, or prior treatment. Statistical analysis was performed to compare the effectiveness among the treatments, and also to uncover the factors influencing the achievement of sustained virological response. A total of 296 patients were included in the study, with the majority receiving sofosbuvir with daclatasvir (59%) or sofosbuvir with simeprevir (26%). Overall sustained virological response rates were approximately 91.6%. For genotype 1, sofosbuvir with daclatasvir had an sustained virological response rate of approximately 95%, while the sustained virological response rate of sofosbuvir with simeprevir was 92%; this difference was statistically significant only for subtype 1b. The only treatment used for genotype 3 patients was sofosbuvir with daclatasvir, and lower rates of sustained virological response were observ...Continue Reading

Citations

Nov 7, 2019·Pharmacoepidemiology and Drug Safety·Camille Nigri CursinoSabrina Calil-Elias
Aug 5, 2020·Journal of Medical Virology·Ezequiel RidruejoUNKNOWN Latin American Liver Research Educational and Awareness Network (LALREAN)
Nov 22, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Fabiane Mateus SiqueiraRoberto Pontarolo
May 8, 2019·Journal of Gastroenterology and Hepatology·Flavia F FernandesHugo Perazzo
Jun 25, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Vinicius Lins FerreiraRoberto Pontarolo
Dec 5, 2019·Arquivos De Gastroenterologia·Andréa Delfino TorresCarla Vitola Gonçalves
Feb 4, 2021·Revista Do Instituto De Medicina Tropical De São Paulo·Isabella Patrícia Lima SilvaHeloisa Ramos Lacerda
Apr 10, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Simone Monzani VivaldiniWildo Navegantes de Araújo
Jul 24, 2020·Value in Health Regional Issues·Karin Hepp SchwambachCarine Raquel Blatt

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