Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine

Drugs
A V Bono, S Cuffari

Abstract

Opioid analgesics represent one of the most important tools in a sequential pharmacological approach to oncological pain relief. They are recommended by the WHO when nonsteroidal anti-inflammatory drugs (NSAIDs) no longer provide adequate analgesia. However, the use of opioids is limited because of their numerous and often severe adverse effects. This aspect of opioids has motivated continuous research projects aimed at discovering drugs that can provide maximum pain relief but with improved tolerability. Tramadol is a new, centrally acting analgesic with a dual mechanism of action. It shows a selective interaction with mu receptors, which are responsible for nociception, and has weak pharmacodynamic activity on other opioid receptors. At the same time, it acts synergistically on neuroamine transmission by inhibiting synaptic noradrenaline (norepinephrine) reuptake and inducing intrasynaptic serotonin (5-hydroxytryptamine; 5-HT) release. From a pharmacokinetic standpoint, tramadol offers high bioavailability, with similar patterns after oral or parenteral administration (half-life 5 to 7 hours, time to peak plasma concentration 3.1 hours, and approximately 20% plasma protein binding). Although the efficacy of tramadol is compar...Continue Reading

Citations

Jul 13, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mellar P Davis
Apr 12, 2011·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masaaki HirouchiTakeshi Nishimura
Apr 3, 2012·Drugs & Aging·Eric Prommer, Brandy Ficek
Sep 19, 2017·Expert Opinion on Drug Discovery·Lidia BravoEsther Berrocoso
Sep 2, 2000·Anaesthesia and Intensive Care·E A Shipton
May 3, 2007·Journal of Palliative Medicine·Gary M Reisfield, George R Wilson
Jan 26, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wojciech Leppert, Jacek Łuczak
Jan 19, 2010·Pharmacological Reports : PR·Wojciech Leppert
Apr 1, 2015·The Cochrane Database of Systematic Reviews·Mia Schmidt-HansenJennifer S Hilgart
Dec 17, 2015·BMJ Supportive & Palliative Care·Mia Schmidt-HansenStephanie Arnold
May 17, 2017·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore
Mar 16, 2019·The Journal of Pharmacology and Experimental Therapeutics·Henrique Ballassini AbdallaHarvinder Singh Gill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.