Effectiveness of 1 dose of 2009 influenza A (H1N1) vaccine at preventing hospitalization with pandemic H1N1 influenza in children aged 7 months-9 years

The Journal of Infectious Diseases
James L HadlerJane R Zucker

Abstract

The availability of a well-established immunization registry to provide vaccination information, a school-located vaccination campaign followed by continued 2009 influenza A (H1N1) (pH1N1) activity, and a requirement to report hospitalized influenza cases provided an opportunity to estimate vaccine effectiveness (VE) of an initial dose of pH1N1 monovalent vaccine in children aged 7 months-9 years. Seventy-eight case children and 729 date-of-birth- and zipcode-matched controls were studied. The VE of a single vaccine dose in preventing pH1N1 hospitalization ≥ 14 days after vaccination was 82% (95% confidence interval [CI], 0%-100%; P = .04) in children aged 3-9 years but was zero (-3%; 95% CI, <0%-75%) in children aged 7-35 months. These findings are consistent with those from prelicensure immunogenicity studies and have implications for interpretation of immunogenicity studies and setting priorities for vaccination of young children in future pandemics. Immunization registries can provide a simple, rapid assessment of VE to evaluate and inform vaccination policy.

Citations

Apr 25, 2013·Nanomedicine·Abdullah A H Ahmad FuaadIstvan Toth
Mar 25, 2014·Emerging Infectious Diseases·Roopa Kalyanaraman MarcelloJane R Zucker
Mar 29, 2014·The Journal of Infectious Diseases·Jill M FerdinandsUNKNOWN Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Sep 16, 2015·Expert Review of Vaccines·Kathleen CoelinghRam Yogev
Dec 29, 2013·Academic Pediatrics·Michael L JacksonDavid C Grossman
Apr 18, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yukako YokouchiYuji Koike
Feb 21, 2013·Human Vaccines & Immunotherapeutics·Eileen A CurranSaad B Omer
Feb 14, 2018·Influenza and Other Respiratory Viruses·Catherine L KingJulie Leask
Sep 1, 2018·The Pediatric Infectious Disease Journal·Inge M L AhoutUNKNOWN Dutch H1N1 Research Group
Sep 16, 2014·The Pediatric Infectious Disease Journal·Karen L KotloffMark Wolff
Nov 15, 2019·Journal of the Pediatric Infectious Diseases Society·Suchitra RaoEdwin J Asturias
Apr 8, 2020·Cold Spring Harbor Perspectives in Medicine·Kanta Subbarao

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