Effectiveness of a Multimedia Educational Intervention to Improve Understanding of the Risks and Benefits of Palliative Chemotherapy in Patients With Advanced Cancer: A Randomized Clinical Trial.

JAMA Oncology
Andrea C EnzingerDeborah Schrag

Abstract

Despite requirements of informed consent, patients with advanced cancer often receive palliative chemotherapy (PC) without understanding that the likelihood of cure is remote. To determine whether a PC educational video and booklet at treatment initiation could improve patients' understanding of its benefits and risks. Regimen-specific PC videos and booklets presenting information about logistics, potential benefits, life expectancy (optional), adverse effects, and alternatives. Videos featured authentic patients sharing diverse experiences. After receiving treatment recommendations, research assistants distributed materials to patients for independent review. Multicenter randomized clinical trial of patients with advanced colorectal or pancreatic cancer starting first-line or second-line PC in 5 US cancer centers with enrollment from June 2015 to September 2017 and follow-up to December 2019. The primary outcome was accurate expectations of chemotherapy benefits at 3 months, defined as responding "not at all likely" to "What is your understanding of how likely the chemotherapy is to cure your cancer?" (from the Cancer Care Outcomes Research and Surveillance study). Secondary outcomes included understanding of adverse effects, ...Continue Reading

Associated Clinical Trials

Nov 4, 2014·Deborah Schrag, MD, Deborah Schrag, MD

References

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Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Natasha B LeighlMartin H N Tattersall
Oct 26, 2012·The New England Journal of Medicine·Jane C WeeksDeborah Schrag
Oct 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea C EnzingerHolly G Prigerson
Mar 17, 2016·Patient Education and Counseling·Kathleen M MazorNeeraj K Arora
Apr 1, 2017·Patient Education and Counseling·Andrea C EnzingerDeborah Schrag
Sep 2, 2017·BMC Medical Informatics and Decision Making·Linda J M OostendorpPeep F M Stalmeier

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