Effectiveness of a nationwide infant immunization program against Haemophilus influenzae b. The Israeli Pediatric Bacteremia and Meningitis Group

Vaccine
R DaganA Leventhal

Abstract

An ongoing nationwide prospective surveillance program for invasive H. influenzae b (Hib) disease in Israel enabled us to study the effectiveness of a national infant Hib immunization program, which included all infants born since January 1994. The vaccine used was Hib polysaccharide conjugated to outer membrane protein complex of Neisseria meningitidis b (PRP-OMPC). For the cohort born during the 3 years since January 1994, the vaccine effectiveness was 94.9% for all invasive Hib diseases and 96.6% for meningitis. The efficacy in fully immunized subjects was 98.7 and 99.5%, respectively. A herd immunity effect could be observed, since a reduction in cases also occurred among infants too young to be immunized. No increase in invasive cases caused by S. pneumoniae and N. meningitidis was observed during the study period. This is the first report outside North America and Western Europe that demonstrates a nationwide extensive reduction of invasive Hib disease within a short time of the introduction of Hib conjugate vaccines to the infant immunization program.

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Citations

Mar 7, 2002·International Journal of Pediatric Otorhinolaryngology·Matitiahu BerkovitchIda Boldur
Apr 23, 2003·Vaccine·Katherine L O'Brien, Ron Dagan
Dec 11, 2003·Annals of Epidemiology·Angela DomínguezUNKNOWN Working Group on Invasive Disease Caused by Haemophilus influenzae
Jun 29, 2007·The Pediatric Infectious Disease Journal·Rita CardinesMarina Cerquetti
Jul 5, 2003·Journal of Clinical Microbiology·Joshua M O'NeillGordon E Schutze
Oct 18, 2011·Paediatric Drugs·Shruti Agrawal, Simon Nadel
Jan 22, 2014·The Pediatric Infectious Disease Journal·Ellen E BambergerUNKNOWN Israeli Pediatric Bacteremia and Meningitis Group
Sep 15, 2009·Lancet·James P WattUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
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May 21, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Esin OcaktanNejat Akar
Apr 2, 2009·Dermatologic Therapy·Natalia MendozaRosella Creed
Apr 23, 2015·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Abhishek SharmaSusan Richardson
Sep 4, 2012·Vaccine·Terri B HydeUNKNOWN New Vaccine Introduction Impact Published Literature Working Group
Apr 26, 2008·Journal of Korean Medical Science·Sangjin ShinMoran Ki
Aug 4, 2001·Revista de saúde pública·D P WeissH Guess
Feb 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Evan J AndersonRam Yogev
Oct 20, 2017·Human Vaccines & Immunotherapeutics·Guijun NingWeizhong Yang
May 16, 2021·The Pediatric Infectious Disease Journal·Bit Gyeol KimJihye Kim

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