Abstract
To quantitatively determine, in a Pseudomonas keratitis model, the anti-inflammatory and bactericidal properties of a new formulation of tobramycin (0.3%) and dexamethasone (0.05%) that utilizes a xanthan gum vehicle. In a randomized and masked fashion, rabbit corneas (n>/=16 eyes per group) were intrastromally injected with 10(3) colony-forming units (CFU) of P. aeruginosa. Eyes were untreated or were administered a single drop every 15 min between 16 and 17 h postinfection (PI) and then a single drop every 30 min between 17 and 22 h PI, a total of 15 drops of either 0.1% dexamethasone and 0.3% tobramycin (TobraDex; Tdex) or a new formulation 0.3% tobramycin and 0.05% dexamethasone with xanthan gum (TobraDex ST; ST). Slit lamp examination scores (SLE+/-SEM) were derived from grading seven parameters at 22 h PI. Rabbits were sacrificed at 23 h PI and the log CFU+/-SEM per cornea was determined. Untreated eyes had SLE scores of 11.11+/-0.43 and had log CFU of 7.27+/-0.06. Eyes treated with Tdex, as compared to the untreated eyes, had significantly lower SLE scores (7.39+/-0.21, p<0.0001) and significantly fewer bacteria (6.32+/-0.29 log CFU, p=0.0213). Eyes treated with ST had a SLE score (6.56+/-0.19) that was significantly low...Continue Reading
References
Jan 1, 1978·Archives of Ophthalmology·S D DavisR A Hyndiuk
Sep 1, 1978·American Journal of Ophthalmology·H M LeibowitzR L Kimbrough
Jul 1, 1980·Archives of Ophthalmology·H M Leibowitz, A Kupferman
Mar 1, 1995·Current Eye Research·L S EngelR J O'Callaghan
Nov 1, 1994·Cornea·J P GuzekR M Aprecio
Sep 1, 1993·Antimicrobial Agents and Chemotherapy·J A HobdenR J O'Callaghan
May 1, 1993·Current Eye Research·J A HobdenR J O'Callaghan
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·G MeseguerR Gurny
Feb 1, 2002·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Charles N J McGheeHelen Danesh-Meyer
Apr 12, 2002·Journal of Pharmaceutical Sciences·Jens CeulemansAnnick Ludwig
Aug 9, 2002·DNA and Cell Biology·Joseph J DajcsRichard J O'Callaghan
Oct 13, 2004·Clinical Therapeutics·Ricardo NotivolUNKNOWN C-98-64 Study Group
Jun 22, 2005·Cornea·Sean D AdreanMark J Mannis
Nov 8, 2005·Eye·S RussoG Milazzo
Feb 17, 2007·Eye·A M S Morley, C Pavesio
May 26, 2007·Clinical Drug Investigation·Ricardo NotivolUNKNOWN International TobraDex Study Group
May 29, 2007·Advances in Therapy·Steven S Rhee, Francis S Mah
Jul 13, 2007·The Journal of Antimicrobial Chemotherapy·Marion GrareRaphaël Emmanuel Duval
Sep 8, 2007·Ophthalmology·Marios ConstantinouHugh R Taylor
Sep 22, 2007·The Journal of Pharmacy and Pharmacology·C Umamaheswara ReddyB S R Reddy
Oct 13, 2007·European Journal of Ophthalmology·F I CamesascaUNKNOWN Italian Betamethasone-Chloramphenicol vs Dexamethasone-Tobramycin Combination Study Group
Oct 27, 2007·Investigative Ophthalmology & Visual Science·Richard J O'CallaghanJonathan D Fratkin
Dec 8, 2007·Current Medical Research and Opinion·Eric M WhiteTimothy L Comstock
Oct 7, 2008·Advances in Therapy·Stephen V Scoper
Citations
Nov 4, 2010·Advances in Therapy·Charles L BalzliRichard J O'Callaghan
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Mary E Marquart
Jul 14, 2012·Clinical Ophthalmology·Mark Dp Willcox
Feb 22, 2012·Zoological Research·Sheng-An LiYun Zhang
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
Dec 25, 2010·Veterinary Ophthalmology·Alan L Weiner, Brian C Gilger
Aug 6, 2013·The Journal of Infection·Kang ChenXi Huang
Nov 8, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Joshua Seth EatonChristopher J Murphy
Feb 6, 2016·Molecular Medicine Reports·Kang ChenXiumin Zhang
Jul 22, 2017·International Journal of Molecular Medicine·Litao GuoXiaobo Tan