Effectiveness of a prevention of mother-to-child HIV transmission programme in an urban hospital in Angola.

PloS One
Cristina LussianaMarco Floridia

Abstract

Antiretroviral therapy is effective in reducing rates of mother-to child transmission of HIV to low levels in resource-limited contexts but the applicability and efficacy of these programs in the field are scarcely known. In order to explore such issues, we performed a descriptive study on retrospective data from hospital records of HIV-infected pregnant women who accessed in 2007-2010 the Luanda Municipal Hospital service for prevention of mother-to-child transmission (PMTCT). The main outcome measure was infant survival and HIV transmission. Our aim was to evaluate PMTCT programme in a local hospital setting in Africa. Data for 104 pregnancies and 107 infants were analysed. Sixty-eight women (65.4%) had a first visit before or during pregnancy and received combination antiretroviral treatment (ART) in pregnancy. The remaining 36 women (34.6%) presented after delivery and received no ART during pregnancy. Across a median cohort follow-up time of 73 weeks, mortality among women with and without ART in pregnancy was 4.4% and 16.7%, respectively (death hazard ratio: 0.30, 95% CI 0.07-1.20, p = 0.089). The estimated rates of HIV transmission or death in the infants over a median follow up time of 74 weeks were 8.5% with maternal A...Continue Reading

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Citations

Jun 8, 2013·Current Opinion in HIV and AIDS·Rose WilcherWillard Cates
Oct 1, 2013·Enfermedades infecciosas y microbiología clínica·Katie Badillo-NavarroPablo Rojo-Conejo
Jan 7, 2014·Tropical Medicine & International Health : TM & IH·Emanuel M MwendoJim Todd
Sep 23, 2014·Tropical Medicine & International Health : TM & IH·M Bjerregaard-AndersenM Sodemann
Apr 18, 2015·Journal of Public Health·Gonçalo Figueiredo Augusto
Oct 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Menard L ChihanaJudith R Glynn
Oct 8, 2020·Revista Do Instituto De Medicina Tropical De São Paulo·Abilene do Nascimento GouvêaStella Regina Taquette
Oct 29, 2020·Infectious Diseases and Therapy·Chalachew Adugna WubnehAklilu Endalamaw
Oct 28, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Karen HampandaLisa Abuogi

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS

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