Effectiveness of a unique dihydropyridine (BAYTG 1000) for prevention of laminitis in horses

American Journal of Veterinary Research
D M HoodIlka P Wagner

Abstract

To determine whether a unique dihydropyridine (BAYTG 1000) would be beneficial in preventing laminitis in horses. 16 clinically normal adult horses. 8 pairs of horses were used in a controlled double-blind study, using sex- and age-matched horses randomly assigned to treatment or control groups. Horses were subjected to carbohydrate overload to induce laminitis. Treated horses were administered BAY TG 1000 (30 mg/kg, PO, q 24 h) for 3 days. Hoof wall surface temperature (HWST) and lameness were recorded at 4-hour intervals. The HWST was adjusted on the basis of time of onset of lameness and evaluated, using a repeated-measures ANOVA. Lameness 8 hours after onset and clinical status 72 hours after onset of lameness were evaluated, using Mann-Whitney procedures. Analysis revealed that BAYTG 1000 did not decrease the incidence of lameness but significantly ameliorated prodromal hypothermia, lessened the severity of lameness 8 hours after onset of lameness, and improved the clinical status of horses 72 hours after onset of lameness. Results support the conclusion that BAYTG 1000 was protective when used in prevention of laminitis. The drug decreased severity and improved clinical status (recovery) of induced lameness, which was int...Continue Reading

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Citations

Feb 21, 2004·The Veterinary Journal·Simon R BaileyJonathan Elliott
Sep 19, 2001·American Journal of Veterinary Research·D M HoodM K Chaffin
May 16, 2002·American Journal of Veterinary Research·Tracy K HoffIlka P Wagner
Feb 5, 2008·American Journal of Veterinary Research·Nicola J Menzies-GowJonathan Elliott
Apr 13, 2010·The Veterinary Clinics of North America. Equine Practice·Henry W Heymering
Apr 13, 2010·The Veterinary Clinics of North America. Equine Practice·Henry W Heymering
Jun 15, 2006·The Journal of Nutrition·Patricia HarrisAnnette Longland

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