Effectiveness of acyclovir in the treatment of pityriasis rosea. A systematic review and meta-analysis.

Anais Brasileiros De Dermatologia
Milton Rodriguez-ZunigaHerney Garcia-Perdomo

Abstract

There is a lack of evidence to support acyclovir administration in pityriasis rosea. To determine the efficacy of acyclovir in patients with typical pityriasis rosea. A systematic review and meta-analysis of experimental studies was performed in MEDLINE, SCOPUS, EMBASE and others, from January 1990 to October 2016 on acyclovir for pityriasis rosea. Random effect model was used to find the pooled Risk Ratio. Outcomes, evaluated between weeks 1 to 8, were regression of lesions, cessation of lesions, decrease of symptoms and duration of disease. Comparisons were acyclovir vs. placebo; acyclovir vs. symptomatic treatment; acyclovir vs. antibiotic; acyclovir vs. observation and combined therapy (acyclovir plus symptomatic treatment) vs. symptomatic treatment alone. Seven papers were analyzed with 324 participants, of which 159 received acyclovir and 165 were controls. Acyclovir was superior to placebo for complete regression of lesions at week 1 (Risk Ratio 5.72, CI95% 2.36-13.88). However, combined therapy was not superior to symptomatic treatment at week 4 (Risk Ratio 1.46, CI95% 0.93-2.29). Individual studies showed the superiority of acyclovir for the control of symptoms and pruritus. We faced differences designs of trials and i...Continue Reading

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Citations

Nov 7, 2019·The Cochrane Database of Systematic Reviews·Jose Contreras-RuizMaria de Lourdes Silbermann-Reynoso
Dec 17, 2020·Dermatologic Therapy·Maria Cristina Pedrazini, Francisco Carlos Groppo
Apr 27, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·J M Busto-LeisP Herranz-Pinto
Sep 24, 2020·Current Pediatric Reviews·Alexander K C LeungKam Lun Hon

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