Effectiveness of Adjuvant Chemotherapy for Locally Advanced Bladder Cancer

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Matthew D GalskyJuan P Wisnivesky

Abstract

Given that randomized trials exploring adjuvant chemotherapy for bladder cancer have been underpowered and/or terminated prematurely, yielding inconsistent results and creating an evidence gap, we sought to compare the effectiveness of cystectomy versus cystectomy plus adjuvant chemotherapy in real-world patients. We conducted an observational study to compare the effectiveness of adjuvant chemotherapy versus observation postcystectomy in patients with pathologic T3-4 and/or pathologic node-positive bladder cancer using the National Cancer Data Base. We compared overall survival using propensity score (-adjusted, -stratified, -weighted, and -matched) analyses based on patient-, facility-, and tumor-level characteristics. A sensitivity analysis was performed to examine the impact of performance status. A total of 5,653 patients met study inclusion criteria; 23% received adjuvant chemotherapy postcystectomy. Chemotherapy-treated patients were younger and more likely to have private insurance, live in areas with a higher median income and higher percentage of high school-educated residents, and have lymph node involvement and positive surgical margins (P < .05 for all comparisons). Stratified analyses adjusted for propensity score...Continue Reading

References

Jun 13, 2003·Lancet·UNKNOWN Advanced Bladder Cancer Meta-analysis Collaboration
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael Froehner
Mar 26, 2009·American Journal of Epidemiology·Elizabeth A StuartPhilip Leaf
Jan 1, 2005·Journal of the National Comprehensive Cancer Network : JNCCN·Matthew D GalskyDean E Bajorin
Jul 24, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert S SvatekColin P N Dinney
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Collaboration of TrialistsMahesh K B Parmar
Jun 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C M BoothW J Mackillop
Sep 6, 2014·Journal of the National Cancer Institute·Kristian D StenslandMatthew D Galsky
Sep 1, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C M BoothW J Mackillop

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Citations

Jun 17, 2016·Future Oncology·Jeanny B Aragon-Ching, Donald L Trump
Nov 23, 2016·Nature Reviews. Clinical Oncology·Samuel A Funt, Jonathan E Rosenberg
Jan 31, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John R BergquistMark J Truty
Jan 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sumanta K PalToni Choueiri
Jan 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guru SonpavdeJeffrey W Nix
Jul 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Enzo Maria RuggeriFabrizio Nelli
Jul 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yu-Wen Hu
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew D GalskyBart Ferket
Jun 18, 2017·Urologia·Gabriella Del Bene, Cora N Sternberg
Jun 1, 2018·Expert Review of Anticancer Therapy·Yuval FreifeldVitaly Margulis
Jun 27, 2018·Journal of Comparative Effectiveness Research·Jessica DaviesGracy Crane
Mar 22, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Safiya Karim, Christopher M Booth
Mar 12, 2019·Current Opinion in Urology·Patrick J EulittMatthew I Milowsky
Aug 31, 2019·Expert Review of Anticancer Therapy·Armando StabileAlberto Briganti
Jun 6, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Elizabeth R KesslerStacy M Fischer
Jun 18, 2020·Expert Review of Anticancer Therapy·Rohit K Jain, Guru Sonpavde
May 18, 2016·Anti-cancer Drugs·Carlo CattriniFrancesco Boccardo
Mar 16, 2017·Nature Reviews. Urology·Daniel P Nguyen, George N Thalmann
Mar 11, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumitaka ShimizuShigeo Horie
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Jeanny B Aragon-ChingGary D Steinberg
Jan 27, 2019·World Journal of Urology·Jeffrey J LeowArnulf Stenzl
May 2, 2020·World Journal of Urology·Luca AfferiUNKNOWN European Association of Urology-Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group
Aug 9, 2020·CA: a Cancer Journal for Clinicians·Vaibhav G PatelMatthew D Galsky
Dec 31, 2016·Bladder Cancer·Lakshminarayanan Nandagopal, Guru Sonpavde
May 29, 2018·Current Treatment Options in Oncology·Rosa Nadal, Andrea B Apolo
Feb 26, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M RouprêtA Méjean
Jan 6, 2021·Der Urologe. Ausg. A·Alexander TamalunasJozefina Casuscelli
Nov 17, 2020·Frontiers in Oncology·Paolo Andrea ZucaliArmando Santoro

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