Effectiveness of antimicrobial stewardship programmes in neonatology: a systematic review

Archives of Disease in Childhood
A R Araujo da SilvaW Zingg

Abstract

Antimicrobial stewardship programmes (ASPs) are recommended to improve antibiotic use in healthcare and reduce antimicrobial resistance (AMR). Our aim was to investigate the effectiveness of ASPs in reducing antibiotic consumption, use of broad-spectrum/restricted antibiotics, antibiotic resistance and healthcare-associated infections (HAIs) in neonates. We searched PUBMED, SCIELO, EMBASE and the Cochrane Database (January 2000-April 2019) to identify studies on the effectiveness of ASPs in neonatal wards and/or neonatal intensive care units (NICUs). Outcomes were as follows: reduction of antibiotic consumption overall and of broad-spectrum/target antibiotics, inappropriate antibiotic use, antibiotic resistance and HAIs. ASPs conducted in settings other than acute care hospitals, for children older than 1 month, and ASPs addressing antifungal and antiviral agents, were excluded. The initial search identified 53 173 titles and abstracts; following the application of filters and inclusion criteria, a total of six publications were included in the final analysis. All studies, of which one was multi-centre study, were published after 2010. Five studies were conducted exclusively in NICUs. Four articles applied multimodal interventi...Continue Reading

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Citations

Apr 4, 2021·Antibiotics·Ioannis Kopsidas Preventing Hospital-Acquired Infections In Greece PHiG Investigators
Aug 3, 2021·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Juan C Lona-ReyesHerlinda Pinto-Macedo
Aug 31, 2021·The Journal of Pediatrics·Siyuan JiangUNKNOWN REIN-EPIQ Study Group

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