PMID: 15220704Jun 29, 2004Paper

Effectiveness of antiretroviral therapy among patients who attend public HIV clinics in Rio de Janeiro, Brazil

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Cristina B HoferLee H Harrison

Abstract

Brazil provides antiretroviral therapy (ART) to HIV-infected persons free of charge. The objective of this study was to investigate factors associated with ART failure in patients receiving free ART in public clinics in Brazil. This is a cross-sectional study of adults taking ART for 6 to 24 months in 5 public clinics in Rio de Janeiro. Patients were interviewed and their charts were reviewed. The following definitions of response to therapy at 6 months were used: virologic responders (VR), > or =1 log reduction in plasma viral load (VL); immunologic responders (IR), increase of > or = 50 CD4 cells/mL; complete responders (CR), both VR and IR; and nonresponders (NR), neither VR nor IR. Of 211 patients enrolled, 173 (82%) were VR, IR, or CR and 38 (18%) were NR. Of the responders, 28 (13%) were IR, 32 (15%) were VR, and 113 (53%) were CR. In multivariate analysis, factors associated with NR were less than 80% adherence (OR = 8.6; 95% CI, 2.9-25.7), baseline CD4 count (OR = 0.5 per 50 cells/mL; 95% CI, 0.2-1.1), interval between starting ART and first VL/CD4 testing (OR = 1.4 for each month; 95% CI, 1.1-1.8), opportunistic disease after starting ART (OR = 6.8; 95% CI, 1.4-34.0), inability to read prescription (OR = 3.9; 95% CI, 1...Continue Reading

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Citations

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