PMID: 9181316Jun 1, 1997Paper

Effectiveness of automated cervical cytology rescreening using the AutoPap 300 QC System

Diagnostic Cytopathology
M W StevensL Kuan

Abstract

This study assesses the performance of the AutoPap 300 QC System in identifying false-negative (FN) smears in a slide population previously screened as normal and compares the detection rate to that achieved with a random rescreen of the same slide population. A total of 1,840 "normal" smears were rescreened both manually and by the AutoPap 300 QC System. Overall, a total of 7 FN slides were detected. At QC selection rates of 30% and 20% the device achieved sensitivities for detection of FN smears of 57.19% (4/7) and 42.8% (3/7), respectively. This represents a three- to fourfold enrichment in the number of FN smears over that obtained by a random rescreen of a similar proportion of cases. None of the FN slides were identified by either method at a 10% rescreening rate. The ability of the device to detect slides previously classified as abnormal (n = 139) and FN (n = 40) was also studied. The overall sensitivity to abnormal smears at QC selection rates of 10%, 20%, and 50% was 61.9%, 77.0%, and 94.2%, respectively. Improved sensitivity to smears classified as LSIL or worse (n = 112) was obtained for corresponding selection rates (61.6%, 75.9%, and 93.8%). Sensitivity to FN slides classified as LSIL or worse (n = 17) for QC sele...Continue Reading

References

Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Baker, D H Melcher
Dec 1, 1974·Journal of Clinical Pathology·O A HusainR Yule
Jul 1, 1995·Diagnostic Cytopathology·R AshfaqM H Saboorian
Apr 1, 1995·Cytopathology : Official Journal of the British Society for Clinical Cytology·N Dudding
Nov 1, 1994·Acta Anaesthesiologica Scandinavica·T Prien
Aug 1, 1993·Diagnostic Cytopathology·J W GeyerM Kirkpatrick
Jan 1, 1993·Acta Anaesthesiologica Scandinavica·O FjalldalV Magnússon
Jan 1, 1993·Cytopathology : Official Journal of the British Society for Clinical Cytology·C A Faraker
Nov 1, 1995·Diagnostic Cytopathology·G G Birdsong

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Citations

Jun 6, 2000·Journal of Women's Health & Gender-based Medicine·G H Eltabbakh, G D Eltabbakh
Jan 18, 2003·Primary Care·Judith M E Walsh, Stephen J McPhee
May 30, 1998·Journal of the National Cancer Institute·D L Rosenthal
Oct 3, 2002·Diagnostic Cytopathology·Ann E Walts, Premi Thomas
Feb 24, 2005·Clinical Obstetrics and Gynecology·Jennifer RussellChristopher M Zahn
Jul 8, 1999·Obstetrical & Gynecological Survey·O Abulafia, D M Sherer
Nov 8, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·John Doorbar, Heather Cubie

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