Effectiveness of botulinum-A toxin for the treatment of refractory overactive bladder in children

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
A MarteP Parmeggiani

Abstract

We describe our experience with botulinum-A toxin (BTX-A) in children presenting idiopathic overactive bladder (OAB) refractory to anticholinergic drugs. 21 patients, aged 8-12 years, were treated over a 3-year period. BTX-A was administered at a dosage of 12.5 UI /kg body weight, without exceeding 200 UI, at 20 detrusor sites. To ensure a stable solution, each 100 UI of botulinum toxin was diluted with 5 cc saline solution just prior to performing the cystoscopy. No patient presented with severe systemic complications or urinary retention after injection therapy; 6 patients presented with slight hematuria for 2-3 days. The clinical results were as follows. At 6 months, 8/21 patients (38%) showed full response, 12/21 (57%) had a partial response after a 2 (nd) injection, and 1/21 (4.7%) showed no response after a 2 (nd) injection. At 12 months, 16 patients (76%) had a full response, 4 (19%) showed a partial response after a 3 (rd) injection, and 1 patient (4.7%) still had no response. At 18 months, 18 patients (85%) showed a full response, 2 patients (9.5%) had a partial response, 1 patient (4.7%) had no response. At the end of this study, 8/21 patients (38%) were symptom-free, after only one botulinum detrusor injection, 13/21...Continue Reading

Citations

Jan 17, 2012·Pediatric Surgery International·Dermot Thomas McDowellFeargal Quinn
May 15, 2013·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Bogdan Orasanu, Sangeeta T Mahajan
Aug 26, 2014·Journal of Pediatric Surgery·Priscilla LéonMarie-Laurence Poli-Mérol
Feb 4, 2011·Expert Opinion on Pharmacotherapy·Apostolos Apostolidis
Oct 30, 2013·Current Medical Research and Opinion·Howard B GoldmanFady Ntanios
May 11, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Yue-Chen Kuo, Hann-Chorng Kuo
Aug 12, 2015·Nature Reviews. Urology·Yuan-Hong JiangHann-Chorng Kuo
Aug 18, 2016·Nature Reviews. Urology·Israel Franco
Oct 24, 2019·Expert Opinion on Pharmacotherapy·Tiernan Middleton, Pamela Ellsworth
Jan 5, 2021·Current Opinion in Urology·Hatim ThakerMin Dong

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