Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease.

Pituitary
Lucio VilarViviane Canadas

Abstract

The expression of dopamine receptor subtypes has been reported in corticotroph adenomas, and this finding support the possibility for medical treatment of Cushing's disease (CD) with dopamine agonists when conventional treatment has failed. The aim of this study was to evaluate the effectiveness of cabergoline (at doses of up 3 mg/week), alone or combined with relatively low doses of ketoconazole (up to 400 mg/day), in 12 patients with CD unsuccessfully treated by transsphenoidal surgery. After 6 months of cabergoline therapy, normalization of 24 h urinary free cortisol (UFC) levels occurred in three patients (25%) at doses ranging from 2-3 mg/week, whereas reductions ranging from 15.0 to 48.4% were found in the remaining. The addition of ketonocazole to the nine patients without an adequate response to cabergoline was able to normalize UFC excretion in six patients (66.7%) at doses of 200 mg/day (three patients), 300 mg/day (two patients) and 400 mg/day (one patient). In the remaining patients UFC levels did not normalize but a significant reduction ranging from to 44.4 to 51.7% was achieved. In two of the six responsive patients to combination therapy, the weekly dose of cabergoline could be later reduced from 3 to 2 mg. Our ...Continue Reading

References

Oct 9, 1976·Lancet·S W Lamberts, J C Birkenhäger
Oct 30, 1975·The New England Journal of Medicine·D T KriegerF Linick
Aug 1, 1992·Endocrinologia Japonica·L B Mercado-AsisK Miura
May 1, 1992·Endocrine Reviews·J S BevanM F Scanlon
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R J CroughsA M McNicol
Aug 1, 1993·Endocrine Reviews·J W Miller, L Crapo
Jul 1, 1997·Journal of Endocrinological Investigation·A ColaoG Lombardi
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·N Sonino, M Boscaro
Mar 10, 2000·Journal of Endocrinological Investigation·R PivonelloA Colao
Sep 6, 2000·Hormone Research·A ColaoG Lombardi
Feb 15, 2001·European Journal of Endocrinology·P PetrossiansA Beckers
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Apr 4, 2002·Journal of Endocrinological Investigation·G T'SjoenM Vandeweghe
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Rosario PivonelloSteven W J Lamberts
May 16, 2006·Lancet·John Newell-PriceLynnette K Nieman
Jun 1, 2007·Annales d'endocrinologie·L Bricaire, T Brue
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarOscar D Bruno
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Cuong Nguyen Dang, Peter Trainer
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Rosario PivonelloAnnamaria Colao
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Lynnette K NiemanVictor M Montori
Apr 17, 2008·The Journal of Clinical Endocrinology and Metabolism·B M K BillerM Boscaro
Apr 26, 2008·Pituitary·Mary Lee Vance
Aug 7, 2008·The Journal of Clinical Endocrinology and Metabolism·Annamaria ColaoGaetano Lombardi
Jan 15, 2009·The Journal of Clinical Endocrinology and Metabolism·Christiaan de BruinLeo J Hofland
Jan 27, 2009·Journal of Endocrinological Investigation·L VilarL A Casulari
May 6, 2009·Archives of Dermatological Research·L J MaYu-Zhen Li
May 30, 2009·Journal of the American College of Surgeons·Philip W SmithJohn B Hanks
Aug 13, 2010·European Journal of Endocrinology·Ariane GodboutAndré Lacroix

❮ Previous
Next ❯

Citations

Jun 8, 2012·Pituitary·Maria Fleseriu, Stephan Petersenn
Mar 9, 2012·The New England Journal of Medicine·Annamaria ColaoUNKNOWN Pasireotide B2305 Study Group
Aug 31, 2012·Journal of Oncology·Carlotta PozzaAndrea M Isidori
Jun 20, 2012·Orphanet Journal of Rare Diseases·Frederic CastinettiThierry Brue
Sep 1, 2012·Endocrine-related Cancer·R van der PasR A Feelders
Jul 21, 2012·European Journal of Endocrinology·Camille BaudryJérôme Bertherat
Aug 13, 2010·European Journal of Endocrinology·Ariane GodboutAndré Lacroix
Oct 23, 2013·Journal of Neuro-oncology·Nicholas A Tritos, Beverly M K Biller
Jun 6, 2013·Drugs·Rob van der PasRichard A Feelders
Jul 3, 2015·Expert Opinion on Pharmacotherapy·Sara G CreemersRichard A Feelders
May 30, 2015·Expert Opinion on Emerging Drugs·Daniela Guelho, Ashley B Grossman
Feb 26, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M G BaroniUNKNOWN Italian Endocrinological Society (SIE)
Oct 6, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·María-José Barahona Constanzo, Carlos del Pozo Picó
Oct 9, 2012·Neurosurgery Clinics of North America·Maria Fleseriu
Apr 2, 2016·International Journal of Endocrinology·Lucio VilarLuciana Naves
Oct 15, 2013·Clinical Endocrinology·Mônica R Gadelha, Leonardo Vieira Neto
Nov 20, 2015·European Journal of Endocrinology·Pia BurmanJeanette Wahlberg
May 26, 2015·Lancet·André LacroixLynnette K Nieman
Apr 18, 2016·Journal of Endocrinological Investigation·A G Ambrogio, F Cavagnini
Jul 25, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Amir H HamrahianUNKNOWN AACE Neuroendocrine And Pituitary Scientific Committee
Dec 8, 2010·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nalini S ShahPadmavathy Menon
Oct 16, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Pejman Cohan
Dec 3, 2014·Molecular and Cellular Endocrinology·Mark E Molitch
Apr 2, 2015·Endocrinology and Metabolism·Kyu Yeon HurSung Woon Kim
Mar 4, 2015·Endocrinology and Metabolism Clinics of North America·Maria Fleseriu
Jan 4, 2015·Annales d'endocrinologie·Thomas CunyFederico Gatto
Mar 10, 2016·European Journal of Endocrinology·Stuart A MorganGareth G Lavery
Jun 29, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Lynnette K Nieman
Dec 23, 2016·European Journal of Endocrinology·A FerriereA Tabarin
Jul 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Fabiola CostenaroMauro A Czepielewski
Feb 9, 2011·Nature Reviews. Endocrinology·Nicholas A TritosBrooke Swearingen
Jul 27, 2018·Expert Opinion on Pharmacotherapy·Sylvère Störmann, Jochen Schopohl
Aug 20, 2014·The Journal of Endocrinology·Daniel Cuevas-Ramos, Maria Fleseriu
Apr 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Xavier Bertagna, Laurence Guignat
May 18, 2013·Clinical Medicine : Journal of the Royal College of Physicians of London·Amir H Sam, Karim Meeran
Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
Aug 25, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Adriana Albani, Marily Theodoropoulou
Jul 14, 2017·Clinical Diabetes and Endocrinology·Daniel Cuevas-RamosMaria Fleseriu
Sep 1, 2012·Expert Review of Endocrinology & Metabolism·Kelley J MoloneyMarc R Mayberg
Aug 12, 2018·Journal of Endocrinological Investigation·R PaluiH Durgia

❮ Previous
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