Effectiveness of cardiac surgery in patients with trisomy 18: a single-institutional experience

Cardiology in the Young
Yosuke NakaiAkira Mishima

Abstract

Surgical repair for cardiac lesions has rarely been offered to patients with trisomy 18 because of their very short lifespans. We investigated the effectiveness of cardiac surgery in patients with trisomy 18. Patients and methods We performed a retrospective analysis of 20 consecutive patients with trisomy 18 and congenital cardiac anomalies who were evaluated between August, 2003 and July, 2013. All patients developed respiratory or cardiac failure due to excessive pulmonary blood flow. Patients were divided into two subgroups: one treated surgically (surgical group, n=10) and one treated without surgery (conservative group, n=10), primarily to compare the duration of survival between the groups. All the patients in the surgical group underwent cardiac surgery with pulmonary artery banding, including patent ductus arteriosus ligation in nine patients and coarctation repair in one. The duration of survival was significantly longer in the surgical group than in the conservative group (495.4±512.6 versus 93.1±76.2 days, respectively; p=0.03). A Cox proportional hazard model found cardiac surgery to be a significant predictor of survival time (risk ratio of 0.12, 95% confidence interval 0.016-0.63; p=0.01). Cardiac surgery was eff...Continue Reading

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Citations

Mar 10, 2016·American Journal of Medical Genetics. Part a·Tomoki Kosho, John C Carey
Apr 28, 2018·Pediatric Blood & Cancer·Akiko InoueHiroshi Tamai
Apr 2, 2019·American Journal of Medical Genetics. Part a·Jonathan MullinFinella Craig
Sep 28, 2017·Pediatric Cardiology·Renuka PetersonKimberly Spence
Sep 15, 2020·Pediatric Cardiology·Horacio G CarvajalPirooz Eghtesady
Jan 7, 2021·American Journal of Medical Genetics. Part a·Katherine A KosivR Thomas Collins

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