Effectiveness of co-trimoxazole to prevent Plasmodium falciparum malaria in HIV-positive pregnant women in sub-Saharan Africa: an open-label, randomized controlled trial

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Elise KlementEric Caumes

Abstract

Human immunodeficiency virus (HIV) and malaria during pregnancy cause substantial perinatal mortality. As co-trimoxazole (CMX) protects children and HIV-positive adults against malaria, we compared the effectiveness of daily CMX with sulfadoxine-pyrimethamine intermittent preventive treatment (IPT-SP) on malaria risk in HIV-positive pregnant women in a Plasmodium falciparum-endemic African area. From January 2009 to April 2011, we included in a randomized noninferiority trial all HIV type 1-infected pregnant women (≤28 weeks' gestation, CD4 count ≥200 cells/µL, hemoglobin level ≥7 g/L) in 19 health centers in Togo. Women were randomly assigned to daily 800 mg/160 mg CMX, or IPT-SP. The primary outcome was the proportion of malaria-free pregnancies. Other outcomes included malaria incidence, parasitemia, placental malaria, anemia, and infants' birth weight. Of 264 women randomly assigned to the CMX or IPT-SP group, 126 of 132 and 124 of 132, respectively, were included in the analysis. There were 33 confirmed cases of clinical malaria among 31 women in the CMX group, and 19 among 19 women in the IPT-SP group. Ninety-five of 126 (75.4%) women in the CMX group and 105 of 124 (84.7%) in the IPT-SP group remained malaria-free during...Continue Reading

References

Jun 22, 2002·Journal of the American Academy of Dermatology·Muriel EliaszewiczUNKNOWN Epitox Study Group
May 1, 2004·Tropical Medicine & International Health : TM & IH·Amha KebedeAnton M Polderman
Jan 28, 2006·The Lancet Infectious Diseases·Paula E BrentlingerMark A Micek
Jun 14, 2006·BMC Pediatrics·Iyabo T Runsewe-AbiodunBolanle M Fetuga
Nov 17, 2007·The Journal of Infectious Diseases·Feiko O Ter Kuile, Richard W Steketee
Aug 5, 2011·The American Journal of Tropical Medicine and Hygiene·Philip L BulterysMarc Bulterys
Mar 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James D CampbellJordan W Tappero
Jul 6, 2012·The American Journal of Tropical Medicine and Hygiene·Ella T NkhomaSteven R Meshnick

❮ Previous
Next ❯

Citations

Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip L BulterysJulie Gutman
Apr 29, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lise Denoeud-NdamMichel Cot
Apr 29, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elise Klement, Eric Caumes
Jan 27, 2015·The Lancet Infectious Diseases·James A ChurchAndrew J Prendergast
Dec 4, 2014·The Lancet Infectious Diseases·Miguel F CarrascosaJavier Gómez Román
May 4, 2016·PLoS Medicine·Raquel GonzálezClara Menéndez
Jun 28, 2017·Tropical Medicine & International Health : TM & IH·Serge P EholiéAdrien Sawadogo
Feb 10, 2018·British Journal of Clinical Pharmacology·Flory T MuandaAnick Bérard
May 3, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Oriyomi AkinyotuAyodele Arowojolu
Oct 6, 2018·Expert Opinion on Pharmacotherapy·Brioni R Moore, Timothy M E Davis
Mar 15, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ahmed Saadani HassaniJonathan E Kaplan
May 24, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nathan FordLynne Mofenson
Jun 20, 2019·Open Forum Infectious Diseases·Jessica E RayArlene E Dent
May 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia A YuDana Meaney-Delman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Michael E AzikenEtedafe P Gharoro
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Anthony K MbonyePascal Magnussen
The American Journal of Tropical Medicine and Hygiene
Marielle K Bouyou-AkotetMaryvonne Kombila
© 2021 Meta ULC. All rights reserved