Effectiveness of composition based on oxidized dextran in the treatment of grade IIIB skin burns

Bulletin of Experimental Biology and Medicine
V A ShkurupyD V Neshchadim

Abstract

Grade IIIB skin burns were treated with a composition based on oxidized dextran with a molecular weight of 40 kDa (oxidation of 7% glucose residues). On day 32 after burn infliction and from the start of the treatment, the area of skin defect in rats was 30% less than in the group without treatment and by 2.3 times less than in rats treated with panthenol. In rats treated with dextran-based composition or panthenol, the eschar was absent on day 21 after the start of the treatment; by day 32, we found cells of surface epithelium, hair follicles, and sebaceous glands above the scar tissue that were absent in untreated animals; in rats treated with the composition, their number was higher by 2.5 times than in animals treated with panthenol. Treatment with the composition increased volume density (by 2.5 times) and numerical density (by more than 3 times) of blood vessels in the wound and reduced signs of inflammation and fibroplastic activity of fibroblasts in comparison with the corresponding parameters in untreated animals or animals treated with panthenol.

References

Jun 11, 2009·Bulletin of Experimental Biology and Medicine·O V Potapova, V A Shkurupiy
Dec 1, 2010·Bulletin of Experimental Biology and Medicine·N G LuzginaV A Shkurupy
Dec 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Guoming SunSharon Gerecht
Nov 1, 2012·Bulletin of Experimental Biology and Medicine·V A ShkurupiyN G Luzgina
Nov 19, 2014·Bulletin of Experimental Biology and Medicine·V A ShkurupyA M Shestopalov

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Citations

Sep 21, 2021·Bulletin of Experimental Biology and Medicine·M A KarpovA V Troitskii

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