Effectiveness of corticoid pulses in patients with cytokine storm syndrome induced by SARS-CoV-2 infection

Medicina clínica
José Luis Callejas RubioNorberto Ortego Centeno

Abstract

Cytokine storm syndrome (CSS) is a serious complication of COVID-19 patients. Treatment is tocilizumab. The use of glucocorticoids (GC) is controversial. In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. Our objective is to evaluate the efficacy of GC in the CSS by COVID-19. We included 92 patients with CSS associated to COVID-19 who received GC, GC, and tocilizumab and only tocilizumab. We determine CSS markers. We evaluated mortality, intubation, and a combined variable. In all cases the percentages of events were lower in the group of patients with GC was administered. The hazard ratio of the final variables with GC versus the group in which only tocilizumab was administered was lower as CGs were considered, with statistical significance for survival. The early use of GC pulses could control SLC, with a lower requirement to use tocilizumab and a decrease in events such as intubation and death.

Citations

Aug 1, 2020·Expert Review of Respiratory Medicine·Syed Shahzad HasanSyed Tabish Razi Zaidi
Aug 19, 2020·Journal of the Pediatric Infectious Diseases Society·Daniel E DulekHamid Bassiri
Sep 16, 2020·Arthritis & Rheumatology·Alice S ChauBlanka Kaplan
Dec 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Judith van PaassenSesmu M Arbous
Dec 3, 2020·Medicina Clínica·Alejandro Rodríguez-MolineroUNKNOWN en representación del grupo de investigadores para la COVID-19 del Consorci Sanitari de l’Alt Penedès i Garraf (CSAPG)
Feb 16, 2021·Frontiers in Immunology·Tingxuan GuZigang Dong
Feb 16, 2021·Medicina Clínica·José Francisco Pascual ParejaUNKNOWN HUIS-COVID-19 working group
Jan 1, 2021·Medicina clínica·José Francisco Pascual ParejaUNKNOWN en nombre del grupo de trabajo HUIS-COVID-19
Mar 10, 2021·Medicina Clínica·Felipe Blasco Patiño, Ana Elena Guillamón Sánchez
Aug 26, 2020·Medicina clínica·Felipe Blasco Patiño, Ana Elena Guillamón Sánchez
Jul 18, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hadeel AlkofideKhalid M Alkharfy

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