PMID: 9554247Apr 29, 1998Paper

Effectiveness of Cyclofem in the treatment of depot medroxyprogesterone acetate induced amenorrhea

Contraception
M Piya-AnantA Pinol

Abstract

A total of 100 women who were using depot medroxyprogesterone acetate (DMPA) for contraception and who had experienced at least 6 months of drug induced amenorrhea, were randomized to either switching their method of contraception to Cyclofem, or continuing with DMPA. At the end of 6 months, 82% of the Cyclofem users had experienced some vaginal bleeding, compared with 10% of DMPA users. Time to resumption of vaginal bleeding was related to the duration of DMPA use to the duration of DMPA induced amenorrhea, and to the body mass index of the user. Over the 6 months of follow-up, 94% of Cyclofem users complained of some side effects, compared with 22% of DMPA users. The most frequently cited problems among Cyclofem users included breast tenderness, abdominal pain, and dysmenorrhea; yet a third of these women opted to stay on Cyclofem at the end of the study. It is concluded that switching to Cyclofem is a new option for DMPA users who are concerned about amenorrhea. Although using Cyclofem in this setting will not meet the needs of all such women, its effectiveness in inducing vaginal bleeding justifies a trial in those who have no contraindication to estrogen treatment.

Citations

Jun 29, 2010·Archives of Gynecology and Obstetrics·Mostafa Hussein
Jul 21, 2006·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Seo OgbonmwanO Amu
Jul 1, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Banu DaneAhmet Cetin
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Maria F GalloCatherine d'Arcangues

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