PMID: 18709235Aug 19, 2008Paper

Effectiveness of daily and weekly iron supplementation in the prevention of anemia in infants

Revista de saúde pública
Elyne Montenegro EngstromCarlos Augusto Monteiro

Abstract

To evaluate the effectiveness of universal prophylactic targeting with iron sulfate on daily or weekly basis in the prevention of anemia in infants. Randomized clinical field trial with children between ages six and 12 months seen at primary health care units in the municipality of Rio de Janeiro, Brazil, between 2004 and 2005. Three concurrent cohorts were compared: daily group (n=150; 12.5mg Fe/day); weekly group (n=147; 25mg Fe/week) and control group. The intervention consisted of universal supplementation with iron sulfate for 24 weeks, combined with educational adherence-promoting measures. mean serum hemoglobin concentration, distribution and prevalence of anemia (Hb<110.0 g/l) at age 12 months. Effectiveness was evaluated considering both intent to treat and adherence to protocol, using multiple regression analysis (linear and Poisson). Groups were homogeneous in terms of descriptive variables. The intervention was implemented successfully, with high adhesion to protocol in both groups, and no statistical difference between them. After adjustment, only the daily regimen showed a protective effect. Adherence analysis demonstrated an evident dose-response effect on mean Hb and prevalence of anemia only for the daily regim...Continue Reading

Citations

Dec 18, 2015·Journal of Tropical Pediatrics·Tárcio Aragão MatosCecília Costa Arcanjo
Dec 18, 2012·Journal of Tropical Pediatrics·Francisco Plácido Nogueira ArcanjoAlvaro Jorge Madeiro Leite

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